{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:41:10Z","timestamp":1762101670867,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study associations between placental histopathology and stillbirth as well as neonatal outcome in a population born extremely preterm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Stockholm, Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>167 infants born &lt;27 gestational weeks during 2004\u20132007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One senior perinatal pathologist, blinded to outcome data, evaluated all placental slides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Intrauterine fetal death, small\u2010for\u2010gestational age, major neonatal morbidity (intraventricular hemorrhage \u2265grade 3, retinopathy of prematurity \u2265grade 3, necrotizing enterocolitis, cystic periventricular leukomalacia or severe bronchopulmonary dysplasia) and neonatal mortality. Additional outcome variables were Apgar score at 5\u00a0min, sepsis, and treated patent ductus arteriosus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Accelerated villous maturation was associated with a decreased risk for Apgar score &lt;7 at 5\u00a0min (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.041). Fetal thrombosis and low placental weight were associated with an increased risk for both intrauterine fetal death (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011, respectively) and small\u2010for\u2010gestational age (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Placental histology may have prognostic value as it appears to be associated with intrauterine fetal death, as well as with being small\u2010for\u2010gestational age and assignment of a low Apgar score at birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12610","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T06:34:49Z","timestamp":1424759689000},"page":"584-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Placental pathology in relation to stillbirth and neonatal outcome in an extremely preterm population: a prospective cohort study"],"prefix":"10.1111","volume":"94","author":[{"given":"Marie\u2010Therese","family":"Vinnars","sequence":"first","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology Division of Obstetrics and Gynecology Karolinska Institute Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Obstetrics and Gynecology \u00d6rnsk\u00f6ldsviks Hospital \u00d6rnsk\u00f6ldsvik 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