{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:26:56Z","timestamp":1788870416559,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070651"],"award-info":[{"award-number":["81070651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270875"],"award-info":[{"award-number":["81270875"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the different characteristics in Chinese Han women with polycystic ovary syndrome, and to analyze the significance of hyperandrogenism in insulin resistance and other metabolic profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Medical university hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>A total of 229 women with polycystic ovary syndrome aged 18\u201345\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women with polycystic ovary syndrome, diagnosed by Rotterdam criteria, were divided into four groups according to the quartile intervals of free androgen index levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Comparisons between groups were performed using one\u2010way analysis of variance. Stepwise logistic regression analysis was performed to investigate the association between homeostasis model assessment\u2010insulin resistance and independent variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within the four phenotypes, women with phenotype 1 (hyperandrogenism, oligo\/anovulation, and polycystic ovaries) exhibited higher total testosterone, free androgen index, androstenedione, low\u2010density lipoprotein, and lower quantitative insulin sensitivity check index (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05); women with phenotype 4 (oligo\/anovulation and polycystic ovaries) showed lower total cholesterol, low\u2010density lipoprotein, and homeostasis model assessment\u2010insulin resistance, but higher high\u2010density lipoprotein (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). The levels of triglycerides, total cholesterol, low\u2010density lipoprotein, and homeostasis model assessment\u2010insulin resistance significantly increased, but high\u2010density lipoprotein and quantitative insulin sensitivity check index decreased with the elevation of free androgen index intervals. After adjustment for lipid profiles, free androgen index was significantly associated with homeostasis model assessment\u2010insulin resistance in both lean and overweight\/obese women (odds ratio 1.302,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.039 in lean vs. odds ratio 1.132,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036 in overweight\/obese).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Phenotypes 1 and 4 represent groups with the most and least severe metabolic profiles, respectively. Hyperandrogenism, particularly with elevated free androgen index, is likely a key contributing factor for insulin resistance and for the aggravation of other metabolic profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.12612","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T09:34:40Z","timestamp":1424770480000},"page":"494-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Characteristics and contributions of hyperandrogenism to insulin resistance and other metabolic profiles in polycystic ovary syndrome"],"prefix":"10.1111","volume":"94","author":[{"given":"Rong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032046"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031122"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.04.006"},{"key":"e_1_2_8_5_1","first-page":"377","volume-title":"Polycystic ovary syndrome","author":"Zawadski 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