{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:20:20Z","timestamp":1780968020657,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council Australia","award":["ID519225"],"award-info":[{"award-number":["ID519225"]}]},{"name":"NHMRC Senior Research Fellowship","award":["APP1020749"],"award-info":[{"award-number":["APP1020749"]}]},{"name":"NHMRC Peter Doherty Postdoctoral Fellowship","award":["GNT1090778"],"award-info":[{"award-number":["GNT1090778"]}]},{"name":"National Science Foundation","award":["SIDA\/BT\/2005\/04"],"award-info":[{"award-number":["SIDA\/BT\/2005\/04"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association of the fat mass and obesity associated gene (<jats:italic>FTO<\/jats:italic>) rs9939609 single nucleotide polymorphism with recurrent miscarriage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Candidate gene association study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Human Genetics Unit, Colombo, Sri Lanka.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 202 Sinhalese women with two or more first\u2010trimester miscarriages and no living children (cases) and 202 age\u2010 and ethnicity\u2010matched women with no history of miscarriage and having two or more living children (controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood was collected from the participants and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was extracted. Genotyping was performed at the Australian genome Research Facility using the Sequenom MassARRAY system. Genotype and allele frequencies of cases were compared with controls using chi\u2010squared testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The prevalence of the single nucleotide polymorphism in cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the women in the recurrent miscarriage group was 31.9\u00a0\u00b1\u00a00.4\u00a0years and that of the control group was 32.3\u00a0\u00b1\u00a00.3\u00a0years. Of the women in the recurrent miscarriage group, 140 (69.3%) had experienced three or more first\u2010trimester miscarriages. The prevalence of the <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype [<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0002, odds ratio (95% CI)\u00a0=\u00a03.8 (1.8\u20138.0)] and A allele [<jats:italic>p\u00a0<\/jats:italic>=\u00a00.002, odds ratio (95% CI)<jats:italic>\u00a0<\/jats:italic>=\u00a01.6 (1.2\u20132.2)] of the <jats:italic>FTO<\/jats:italic> rs9939609 single nucleotide polymorphism were increased in women in the recurrent miscarriage group compared with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The obesity\u2010related <jats:italic>FTO<\/jats:italic> rs9939609 single nucleotide polymorphism associates with recurrent miscarriage. This finding warrants further investigation with controlling for important factors such as body mass index, diabetes and cardiovascular disease status. The single nucleotide polymorphism may be useful in predicting the risk of recurrent miscarriage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12640","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T22:07:40Z","timestamp":1428012460000},"page":"722-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The obesity\u2010related <i>FTO<\/i> gene variant associates with the risk of recurrent miscarriage"],"prefix":"10.1111","volume":"94","author":[{"given":"Prabha H.","family":"Andraweera","sequence":"first","affiliation":[{"name":"School of Paediatrics and Reproductive Health Robinson Research Institute University of Adelaide Adelaide South Australia Australia"},{"name":"Human Genetics Unit Faculty of Medicine University of Colombo Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustaaf A.","family":"Dekker","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Reproductive Health Robinson Research Institute University of Adelaide Adelaide South Australia Australia"},{"name":"Women's and Children's Division Lyell McEwin Hospital Elizabeth Vale South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan W.","family":"Jayasekara","sequence":"additional","affiliation":[{"name":"Human Genetics Unit Faculty of Medicine University of Colombo Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vajira H.W.","family":"Dissanayake","sequence":"additional","affiliation":[{"name":"Human Genetics Unit Faculty of Medicine University of Colombo Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire T.","family":"Roberts","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Reproductive Health Robinson Research Institute University of 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