{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:04:12Z","timestamp":1773921852189,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To stratify the risk of spontaneous preterm delivery using cervical length (CL<\/jats:styled-content>) and fetal fibronectin (fFN<\/jats:styled-content>) in women with threatened preterm labor who remained pregnant after 7\u00a0days.<\/jats:p><\/jats:sec>Design<\/jats:title>Prospective observational study.<\/jats:p><\/jats:sec>Setting<\/jats:title>Nationwide cohort of women with threatened preterm labor from the Netherlands.<\/jats:p><\/jats:sec>Population<\/jats:title>Women with threatened preterm labor between 24 and 34\u00a0weeks with a valid CL<\/jats:styled-content> and fFN<\/jats:styled-content> measurement and remaining pregnant 7\u00a0days after admission.<\/jats:p><\/jats:sec>Methods<\/jats:title>Kaplan\u2013Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR<\/jats:styled-content>) for spontaneous delivery.<\/jats:p><\/jats:sec>Main outcome measures<\/jats:title>Spontaneous delivery between 7 and 14\u00a0days after initial presentation and spontaneous preterm delivery before 34\u00a0weeks.<\/jats:p><\/jats:sec>Results<\/jats:title>The risk of delivery between 7 and 14\u00a0days was significantly increased for women with a CL<\/jats:styled-content>\u00a0<\u00a015\u00a0mm or a CL<\/jats:styled-content> \u226515 to <30\u00a0mm and a positive fFN<\/jats:styled-content>, compared with women with a CL<\/jats:styled-content> \u226530\u00a0mm: HR<\/jats:styled-content> 22.3 [95% confidence interval (CI<\/jats:styled-content>) 2.6\u2013191] and 14 (95% CI 1.8\u2013118), respectively. For spontaneous preterm delivery before 34\u00a0weeks the risk was increased for women with a CL<\/jats:styled-content>\u00a0<\u00a015\u00a0mm [HR<\/jats:styled-content> 6.3 (95% CI<\/jats:styled-content> 2.6\u201315)] or with a CL<\/jats:styled-content> \u226515 to <30\u00a0mm with either positive fFN<\/jats:styled-content> [HR<\/jats:styled-content> 3.6 (95% CI<\/jats:styled-content> 1.5\u20138.7)] or negative fFN<\/jats:styled-content> [HR<\/jats:styled-content> 3.0 (95% CI<\/jats:styled-content> 1.2\u20137.1)] compared with women with a CL<\/jats:styled-content>\u00a0\u2265\u00a030\u00a0mm.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In women remaining pregnant 7\u00a0days after threatened preterm labor, CL<\/jats:styled-content> and fFN results can be used in risk stratification for spontaneous delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12643","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T16:14:57Z","timestamp":1428077697000},"page":"715-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34\u00a0weeks and not delivering within 7\u00a0days"],"prefix":"10.1111","volume":"94","author":[{"given":"Frederik J.R.","family":"Hermans","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merel M.C.","family":"Bruijn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolande Y.","family":"Vis","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Hematology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke F.","family":"Wilms","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Maastricht Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn A.","family":"Oudijk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina M.","family":"Porath","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology M\u00e1xima Medical Center Veldhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubertina C.J.","family":"Scheepers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Maastricht Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitty W.M.","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline J.","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology VU University Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me M.J.","family":"Cornette","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bas W.A.","family":"Nij Bijvanck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Isala Clinics Zwolle the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen T.M.","family":"Franssen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank P.H.A.","family":"Vandenbussche","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Nijmegen Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolein","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Grobman","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Northwestern University Medical School Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris A.M.","family":"Van Der Post","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.M.","family":"Bossuyt","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology, Biostatistics and Bioinformatics Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent C.","family":"Opmeer","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Academic Medical Center Amsterdam the 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