{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:31:33Z","timestamp":1783967493628,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The sensitivity of conventional colposcopy for the detection of high\u2010grade cervical lesions (cervical intraepithelial neoplasia stage 2 or above; <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+) is poor. We aimed to investigate if a Dynamic Spectral Imaging System (Dy<jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content>) can enhance or replace conventional colposcopy in clinical practice. From 3 December 2013 to 29 January 2014 a total of 239 women were included. All women were referred to the Department of Obstetrics and Gynecology, Aarhus, Denmark because of an abnormal cytology result. Every woman had three to five cervical punch biopsies taken; two biopsies were taken following Dy<jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content> recommendations. Subsequent biopsies were taken following the clinician's assessment or randomly. Dy<jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content> allowed detection of five <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ cases (7.4%) that would not have been detected otherwise, but it failed to detect 46 of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ cases (67.6%). The sensitivity and specificity of Dy<jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content> for detecting <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ was 32.4 and 83.0%, respectively. Dy<jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content> colposcopy seemed inferior to conventional colposcopy in detecting high\u2010grade lesions and cannot replace conventional colposcopy with random biopsies.<\/jats:p>","DOI":"10.1111\/aogs.12646","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T08:01:42Z","timestamp":1428134502000},"page":"781-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Can Dynamic Spectral Imaging System colposcopy replace conventional colposcopy in the detection of high\u2010grade cervical lesions?"],"prefix":"10.1111","volume":"94","author":[{"given":"Mette T.","family":"Roensbo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Blaak\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12279"},{"key":"e_1_2_7_3_1","unstructured":"Sundhedsstyrelsen.Screening For Livmoderhalskr\u00e6ft \u2013 anbefalinger. [Cervical cancer screening \u2013 recommendations]. (In Danish. No abstract available.).2012. Available online at:http:\/\/sundhedsstyrelsen.dk\/publ\/Publ2012\/SYB\/Kraeft\/ScreenLivmoderhalskrftAnbef.pdf(accessed September 17 2014)."},{"key":"e_1_2_7_4_1","unstructured":"DKLS.Dansk Kvalitetsdatabase for Livmoderhalskr\u00e6ftscreening. \u00c5rsrapport 2013. [Danish quality database for cervical screening. Annual report 2013.](In Danish. No abstract available.). Available online at:https:\/\/www.sundhed.dk\/content\/cms\/82\/4682__rsrapport-september_vers3-9_final_23-09-14.pdf(accessed January 16 2015)."},{"key":"e_1_2_7_5_1","unstructured":"EngholmG FerlayJ ChristensenN KejsAMT JohannesenTB KhanS et\u00a0al.NORDCAN: Cancer Incidence Mortality Prevalence and Survival in the Nordic Countries Version 7.0 (17.12.2014).Association of the Nordic Cancer Registries. Danish Cancer Society.2014. Available online at:http:\/\/www-dep.iarc.fr\/NORDCAN\/DK\/StatsFact.asp?cancer=212&country=208(accessed December 20 2014)."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.05.033"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31819308d4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02806.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1636"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03280.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000458"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3181fb4547"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365087"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12646","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:02:10Z","timestamp":1695553330000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,29]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/aogs.12646"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12646","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,29]]},"assertion":[{"value":"2014-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}