{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:56:03Z","timestamp":1773334563031,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether iron contained in ovarian endometriomas can diffuse through the cyst wall and negatively affect ovarian function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Infertility unit in an academic setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Thirty\u2010nine infertile women with unilateral endometriomas who underwent in\u00a0vitro fertilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Iron and ferritin assessments in pools of follicular fluids obtained from affected and contralateral intact gonads.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Iron and ferritin concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follicular fluid iron content did not differ between the two gonads. The median [interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>)] follicular concentrations in the affected and unaffected ovaries were 59 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 44\u201374) and 59 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 47\u201373)\u00a0\u03bcg\/dL, respectively (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.77). Conversely, ferritin concentration was significantly higher in affected gonads. The median (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>) concentrations of ferritin in the affected and unaffected ovaries were 57 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 31\u2013146) and 33 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 23\u201367)\u00a0\u03bcg\/mL, respectively (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.026). When considering together the 78 studied ovaries, no significant correlations emerged between follicular iron and ferritin and variables reflecting ovarian responsiveness and oocyte developmental competence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Iron may diffuse from ovarian endometriomas into the adjacent ovarian tissue. However, this phenomenon does not appear to markedly affect ovarian function. Some effective biological mechanisms such as ferritin storage may effectively sequester free iron, so limiting its detrimental effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12647","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T08:01:48Z","timestamp":1428134508000},"page":"646-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Intrafollicular iron and ferritin in women with ovarian endometriomas"],"prefix":"10.1111","volume":"94","author":[{"given":"Laura","family":"Benaglia","sequence":"first","affiliation":[{"name":"Obstetrics\u2010Gynecology Department Policlinic Maggiore Hospital (Ospedale Maggiore) Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-3161","authenticated-orcid":false,"given":"Alessio","family":"Paffoni","sequence":"additional","affiliation":[{"name":"Obstetrics\u2010Gynecology Department Policlinic Maggiore Hospital (Ospedale Maggiore) Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Mangiarini","sequence":"additional","affiliation":[{"name":"Obstetrics\u2010Gynecology Department Policlinic Maggiore Hospital (Ospedale Maggiore) Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Restelli","sequence":"additional","affiliation":[{"name":"Obstetrics\u2010Gynecology Department Policlinic Maggiore Hospital (Ospedale Maggiore) Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Bettinardi","sequence":"additional","affiliation":[{"name":"Analysis Laboratory Ca\u2019 Granda Foundation Policlinic Maggiore Hospital (Ospedale Maggiore) Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgardo","family":"Somigliana","sequence":"additional","affiliation":[{"name":"Obstetrics\u2010Gynecology Department Policlinic Maggiore Hospital (Ospedale Maggiore) Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Vercellini","sequence":"additional","affiliation":[{"name":"Obstetrics\u2010Gynecology Department Policlinic Maggiore Hospital (Ospedale Maggiore) Milan Italy"},{"name":"University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Fedele","sequence":"additional","affiliation":[{"name":"Obstetrics\u2010Gynecology Department Policlinic Maggiore Hospital (Ospedale Maggiore) Milan Italy"},{"name":"University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000009999"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-005-3802-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590802366204"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798072463"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der211"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.08.068"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03103-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2012.743197"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v024a18"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt053"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det466"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.04.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.02.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6392"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.05.031"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det457"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.056"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.1.50"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg321"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.11.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det087"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03346-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.11.060"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.103"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113477479"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.03.011"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der097"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.03.002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.01.110"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12647","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:02:22Z","timestamp":1695474142000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,30]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/aogs.12647"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12647","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,30]]},"assertion":[{"value":"2014-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}