{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T13:11:17Z","timestamp":1722085877201},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T00:00:00Z","timestamp":1432339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Renal transplant patients are at increased risk for human papillomavirus\u2010related malignancies of the lower genital tract. Our aim was to describe the incidence of genital dysplasia, assess the most common cervical cancer screening intervals and identify independent risk factors for the development of genital dysplasia in renal transplant patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective, non\u2010interventional study from two centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Post\u2010transplant nephrologic follow\u2010up visit at the Medical University of Vienna and a Viennese teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>262 consecutive female renal transplant patients with renal transplant performed between 1980 and 2012 at the Medical University of Vienna.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sociodemographic patient characteristics, frequency of gynecological examinations, histo\u2010 and cytopathological test results were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Dysplasia rates in renal transplant patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>16 patients (6.2%) with genital dysplasia after renal transplant were observed. The 1\u2010year, 3\u2010year and 10\u2010year proportional incidence rates for genital dysplasia in general and cervical dysplasia in particular were 1.3 and 1.3%, 3.3 and 2.7%, and 13.6 and 12.0%, respectively. Patients attended cervical cancer screening on a regular basis once a year in 82.7% of cases. In multivariate analysis re\u2010transplantation [odds ratio 12.1 (1.5\u201396.3)], and renal transplant at a young age [odds ratio 0.6 (0.4\u20130.9)] were identified as independent risk factors for the development of female genital dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Female renal transplant patients have an increased risk for the development of genital dysplasia in general and of cervical dysplasia in particular. Within this cohort, women at a young age at the time of transplantation and after re\u2010transplantation are at highest risk for the development of genital dysplasia<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12663","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T07:16:58Z","timestamp":1429946218000},"page":"891-897","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of genital dysplasia after kidney transplantation \u2013 a retrospective, non\u2010interventional study from two centers"],"prefix":"10.1111","volume":"94","author":[{"given":"Julian","family":"Marschalek","sequence":"first","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Gynecological Cancer Unit Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Helmy","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Gynecological Cancer Unit Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis Department of Medicine Ill Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Polterauer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Gynecological Cancer Unit Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Sobulska","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Gynecological Cancer Unit Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg P.","family":"Gyoeri","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology Gynecological Cancer Unit Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.111"},{"key":"e_1_2_9_4_1","first-page":"905","article-title":"ACOG Practice Bulletin. 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