{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:41:12Z","timestamp":1772790072109,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Genital bleeding may be a common symptom among women with cervical cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Cross\u2010sectional study evaluating whether the prevalence of cervical smear results is different in women with and without clinical information about concurrent genital bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample consisted of 2\u00a0324\u00a0836 smears; of these, 0.4% had clinical information on genital bleeding. When stratified by age group, women with genital bleeding had a higher chance of a cytological result of a high\u2010grade squamous intraepithelial lesion [30\u201349\u00a0years odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 2.38; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.60\u20133.53 and \u226550\u00a0years <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.30; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.72\u201310.67), of squamous cell carcinoma (SCC) (30\u201349\u00a0years <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 24.70; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 11.96\u201351.03 and \u226550\u00a0years <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 48.91; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 31.28\u201376.47) and of atypical glandular cells (30\u201349\u00a0years <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.72; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.30\u20139.93 and \u226550\u00a0years <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 11.56; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 5.96\u201322.45); there was also a higher chance of adenocarcinoma for women \u226550\u00a0years (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 53.13; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 28.08\u2013100.51). The sensitivity of genital bleeding for women aged 18\u201329\u00a0years was 0.4% for high\u2010grade squamous intraepithelial lesion (<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>); for women 30\u201349\u00a0years old the rate was 0.9% for <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>, 8.6% for SCC and 2.1% for atypical glandular cells of undetermined significance (<jats:styled-content style=\"fixed-case\">AGUS<\/jats:styled-content>), while for women aged from 50\u00a0years or more the rates were 2.0% for <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>, 13.7% for SCC, 3.6% for <jats:styled-content style=\"fixed-case\">AGUS<\/jats:styled-content> and 14.7% for adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women \u226530\u00a0years old with genital bleeding should be referred for colposcopy to rule out the possibility of cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12682","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T08:24:47Z","timestamp":1433147087000},"page":"949-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between concurrent genital bleeding and cervical cancer: a cross\u2010sectional study"],"prefix":"10.1111","volume":"94","author":[{"given":"Jos\u00e9 C.C.","family":"Xavier\u2010J\u00fanior","sequence":"first","affiliation":[{"name":"Pathology Department Paulista State University (UNESP) Botucatu Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diama B.","family":"Vale","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Campinas State University (UNICAMP) Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz 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