{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T02:04:09Z","timestamp":1775268249500,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Competitive Rsearch Funding of Pirkanmaa Hospital District","award":["9R033"],"award-info":[{"award-number":["9R033"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>The purpose of this study was to evaluate the real\u2010life performance of high\u2010risk (HR<\/jats:styled-content>) HPV<\/jats:styled-content> testing in the triage of repeat atypical squamous cells of undetermined significance (ASC<\/jats:styled-content>\u2010US<\/jats:styled-content>) and low\u2010grade squamous intraepithelial lesions (LSIL<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and methods<\/jats:title>In 2004\u20132012, 127 women with repeat ASC<\/jats:styled-content>\u2010US<\/jats:styled-content> and 118 women with LSIL<\/jats:styled-content> were triaged with HPV<\/jats:styled-content> testing using either a Hybrid Capture 2\u00ae<\/jats:sup> or Abbott RealTime\u00ae<\/jats:sup> HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> test. The patient charts were retrospectively reviewed for performance of the tests.<\/jats:p><\/jats:sec>Results<\/jats:title>In the repeat ASC<\/jats:styled-content>\u2010US<\/jats:styled-content> group, 40.9% of the women were positive for HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content>. The prevalence of cervical intraepithelial neoplasia grade 2 or worse (CIN<\/jats:styled-content>2+) was 8.7%. The sensitivity of the HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> testing for detection of CIN<\/jats:styled-content>2+ was 90.9% (95% Cl 58.7\u201398.5%), with a specificity of 63.8% (95%CI<\/jats:styled-content> 54.4\u201372.5%). In women \u226530\u00a0years old, the specificity was 70.4%, whereas in younger women it was only 27.8%. The negative predictive value to predict CIN<\/jats:styled-content>3 was 100% (95% CI<\/jats:styled-content> 95.2\u2013100.0%). Of the women with LSIL<\/jats:styled-content>, 68.6% were positive for HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> and the prevalence of CIN<\/jats:styled-content>2+ was 14.4%. The sensitivity of HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> testing for detection of CIN<\/jats:styled-content>2+ was 94.1% (95% CI<\/jats:styled-content> 71.2\u201399.0%), and the specificity 35.6% (95% CI<\/jats:styled-content> 26.4\u201345.8%), respectively. The negative predictive value to predict CIN<\/jats:styled-content>3 was 100% (95% CI<\/jats:styled-content> 90.4\u2013100.0%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> testing seems to be beneficial in the triage of repeat ASC<\/jats:styled-content>\u2010US<\/jats:styled-content> in women \u226530\u00a0years old, but a high prevalence of HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> infection combined with poor specificity limit the use of HPV<\/jats:styled-content> testing in the case of LSIL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12686","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T15:18:29Z","timestamp":1433517509000},"page":"931-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High risk HPV<\/scp> testing in the triage of repeat ASC<\/scp>\u2010US<\/scp> and LSIL<\/scp>"],"prefix":"10.1111","volume":"94","author":[{"given":"Olga","family":"Veijalainen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tampere University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"Tuomisaari","sequence":"additional","affiliation":[{"name":"Science Center Pirkanmaa Hospital District Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina","family":"Luukkaala","sequence":"additional","affiliation":[{"name":"Science Center Pirkanmaa Hospital District Tampere Finland"},{"name":"School of Health Sciences University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"M\u00e4enp\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tampere University Hospital Tampere Finland"},{"name":"School of Medicine University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000501)86:3<429::AID-IJC20>3.0.CO;2-D"},{"key":"e_1_2_9_3_1","unstructured":"Finnish Cancer Register.Mean annual numbers of new cancer cases in 1966\u20102012 by primary site and period FEMALES1 [Internet].2012. 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