{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:50:32Z","timestamp":1781502632860,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Berta Kamprad Cancer Foundation"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In early\u2010stage endometrial carcinoma, there is controversy regarding the prognostic value of the flow cytometric variables <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> ploidy (diploid vs. aneuploid) and S\u2010phase fraction. In Sweden, the former is included in national guidelines despite poor scientific support and the latter is not used clinically. This study investigates the prognostic properties of these variables, together with classical histopathological variables, in multivariate analysis in a stringently stratified material.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Consecutive, population\u2010based patient material restricted to International Federation of Gynecology and Obstetrics (<jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content>) 2009 stage I endometrioid endometrial carcinoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01140) was retrospectively collected from routinely reported data from medical records. Data on age, <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> stage, degree of differentiation, S\u2010phase fraction, <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> ploidy status, and adjuvant treatment were included in the study. Cumulative incidence curves with other causes of death as a competing risk were used for univariable analysis for the primary endpoint endometrial cancer death. Cox proportional hazards regression analysis was used for multivariate modeling of all endpoints, and for univariable analysis for the secondary endpoints overall survival and time to progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An S\u2010phase fraction value of &gt;5.5% was associated with worse outcome (for endometrial cancer death: hazard ratio 2.25; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.38\u22123.67; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, adjusted) and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> ploidy status was not, for all endpoints tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> stage I endometrioid endometrial carcinoma, <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> ploidy status had no prognostic value, whereas the S\u2010phase fraction may be used to identify those with a higher risk of adverse clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12704","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T16:27:19Z","timestamp":1435595239000},"page":"1064-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cell proliferation, measured as flow cytometric S\u2010phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population\u2010based study"],"prefix":"10.1111","volume":"94","author":[{"given":"Rasmus W.","family":"Green","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Division of Oncology and Pathology Lund University and Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna","family":"Engblom","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Division of Oncology and Pathology Lund University and Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Baldetorp","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Division of Oncology and Pathology Lund University and Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Division of Oncology and Pathology Lund University and Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Regional Cancer Center South Region Sk\u00e5ne Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"M\u00e5sb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Division of Oncology and Pathology Lund University and Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Department of Clinical Pathology Laboratory Medicine Scania Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bjurberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Division of Oncology and Pathology Lund University and Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Department of Oncology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Socialstyrelsen.Socialstyrelsen. 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