{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:27:35Z","timestamp":1777980455059,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T00:00:00Z","timestamp":1440806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Uppsala-\u00d6rebro Regional Research Council"},{"name":"Swedish Diabetes Foundation"},{"name":"Praktikertj\u00e4nst AB"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A randomized multicenter study was conducted in the Stockholm\u2010\u00d6rebro areas in Sweden to evaluate how treatment aiming at normoglycemia affects fetal growth, pregnancy and neonatal outcome in pregnant women with severe hyperglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Pregnant women with hyperglycemia defined as fasting capillary plasma glucose &lt;7.0 mmol\/L and a two\u2010hour plasma glucose value \u226510.0 and &lt;12.2 mmol\/L following a 75\u2010g oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) diagnosed before 34 weeks of gestation were randomized to treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a033) or controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a036). Women assigned to the control group were blinded for the <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> results and received routine care. The therapeutic goal was fasting plasma glucose 4\u20135 mmol\/L, and &lt;6.5 mmol\/L after a meal. Primary outcomes were size at birth and number of large\u2010for\u2010gestational age (&gt;90th percentile) neonates. Secondary outcomes were pregnancy complications, neonatal morbidity and glycemic control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The planned number of participating women was not reached. There was a significantly reduced rate of large\u2010for\u2010gestational age neonates, 21 vs. 47%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05. Group differences in pregnancy complications and neonatal morbidity were not detected because of limited statistical power. In total, 66.7% of the women in the intervention group received insulin. Of all measured plasma glucose values, 64.1% were in the target range, 7.2% in the hypoglycemic range and 28.7% above target values. There were no cases of severe hypoglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aiming for normalized glycemia in a pregnancy complicated by severe hyperglycemia reduces fetal growth but is associated with an increased rate of mild hypoglycemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12717","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T15:14:48Z","timestamp":1438182888000},"page":"1181-1187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Randomized controlled study in pregnancy on treatment of marked hyperglycemia that is short of overt diabetes"],"prefix":"10.1111","volume":"94","author":[{"given":"Helena E.","family":"Fadl","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"G\u00e4rdefors","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragnhild","family":"Hjertberg","sequence":"additional","affiliation":[{"name":"UltraGyn Clinic Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Nord","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Persson","sequence":"additional","affiliation":[{"name":"Karolinska Institute Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Schwarcz","sequence":"additional","affiliation":[{"name":"Department 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