{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:00:51Z","timestamp":1782990051861,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We investigated the predictive capacity of mid\u2010trimester cervical length (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>) measurement for spontaneous and iatrogenic preterm birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We performed a prospective observational cohort study in nulliparous women and low\u2010risk multiparous women with a singleton pregnancy between 16<jats:sup>+0<\/jats:sup> and 21<jats:sup>+6<\/jats:sup>\u00a0weeks of gestation. We assessed the prognostic capacity of transvaginally measured mid\u2010trimester <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> for spontaneous and iatrogenic preterm birth (&lt;37\u00a0weeks) using likelihood ratios (<jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>) and receiver\u2010operating\u2010characteristic analysis. We calculated numbers needed to screen to prevent one preterm birth assuming different treatment effects. Main outcome measures were preterm birth &lt;32, &lt;34 and &lt;37\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 11\u00a0943 women, of whom 666 (5.6%) delivered preterm: 464 (3.9%) spontaneous and 202 (1.7%) iatrogenic. Mean CL was 44.1\u00a0mm (SD 7.8\u00a0mm). In nulliparous women, the <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>s for spontaneous preterm birth varied between 27 (95% CI 7.7\u201395) for a CL\u00a0\u2264\u00a020\u00a0mm, and 2.0 (95% CI 1.6\u20132.5) for a <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> between 30 and 35\u00a0mm. For low\u2010risk multiparous women, these <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>s were 37 (95% CI 7.5\u2013182) and 1.5 (95% CI 0.97\u20132.2), respectively. Using a cut\u2010off for CL\u00a0\u2264\u00a030\u00a0mm, 28 (6.0%) of 464 women with spontaneous preterm birth were identified. The number needed to screen to prevent one case of preterm birth was 618 in nulliparous women and 1417 for low\u2010risk multiparous women (40% treatment effect, cut\u2010off 30\u00a0mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In women at low risk of preterm birth, <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> predicts spontaneous preterm birth. However, its isolated use as a screening tool has limited value due to low sensitivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12721","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T06:18:47Z","timestamp":1438582727000},"page":"1223-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["The capacity of mid\u2010pregnancy cervical length to predict preterm birth in low\u2010risk women: a national cohort study"],"prefix":"10.1111","volume":"94","author":[{"given":"Jeanine","family":"van der Ven","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A.","family":"van Os","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology VU University Medical Center Amsterdam the 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