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The study included singleton births in women recorded with connective tissue disease (<jats:italic>n<\/jats:italic> = 851) and reference deliveries from the general population (<jats:italic>n<\/jats:italic> = 2 437 110). Births were stratified in four periods, 1967\u20131979, 1980\u20131989, 1990\u20131999 and 2000\u20132009. Associations between connective tissue disease and maternal and perinatal outcomes by decade were assessed in logistic regression analyses and adjusted for maternal age at delivery and parity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 1970s, around 2.7 deliveries\/year were registered for women with connective tissue disease (0.004% of all deliveries). This increased to 42 deliveries\/year (0.07% of all deliveries) after 2000. Adjusted odds ratios (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>) for cesarean section were 5.0 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u201311.9) in the first and 1.8 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20132.3) in the last period. For preterm delivery the <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> decreased from 4.9 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u201311.4) to 3.1 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.3\u20134.2) and the <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> for birthweight &lt;2500 g changed from 7.3 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.3\u201316.3) to 4.1 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.0\u20135.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An increasing number of births were observed over time among women with connective tissue disease. Adverse pregnancy outcomes were more common among women with connective tissue disease but risks have decreased over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12722","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T05:44:49Z","timestamp":1438407889000},"page":"1195-1202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Secular trends of pregnancies in women with inflammatory connective tissue disease"],"prefix":"10.1111","volume":"94","author":[{"given":"Marianne","family":"Wallenius","sequence":"first","affiliation":[{"name":"National Advisory Unit on Pregnancy and Rheumatic Diseases Department of Rheumatology Trondheim University Hospital Trondheim Norway"},{"name":"Department of Neuroscience Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell \u00c5.","family":"Salvesen","sequence":"additional","affiliation":[{"name":"National Center for Fetal Medicine Department of Obstetrics and Gynecology Trondheim University Hospital Trondheim Norway"},{"name":"Department of Laboratory Medicine Women's and Child Health Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne K.","family":"Daltveit","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Health Care University of Bergen Bergen Norway"},{"name":"Medical Birth Registry of Norway Division of Epidemiology Norwegian Institute of Public Health Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan F.","family":"Skomsvoll","sequence":"additional","affiliation":[{"name":"National Advisory Unit on Pregnancy and Rheumatic Diseases Department of Rheumatology Trondheim University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009749109165287"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e318239e1ee"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100997"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009749950155337"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2000.079006490.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22373"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6399.1088"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00240110"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2000.079006435.x"},{"key":"e_1_2_8_12_1","unstructured":"European surveillance of congenital anomalies EUROCAT: Guide 1.4 chapter 3.3:coding of EUROCAT subgroups of congenital anomalies. 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