{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:14:12Z","timestamp":1781892852384,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fatal antepartum fetomaternal hemorrhage is a relatively uncommon clinical presentation, though one that appears quickly and without warning. The pathophysiology of this disease is unclear, and the incidence does not appear to be decreasing in line with overall antepartum mortality. This study was undertaken to analyse trends in antepartum fetal death from fetomaternal hemorrhage over a 25\u2010year period in a single maternity hospital in Dublin, Ireland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A cross\u2010sectional study of 192\u00a0132 nonanomalous infants weighing 500\u00a0g or more, delivered in a single tertiary\u2010referral university institution between 1987 and 2011. Data was compared using Fisher's exact test, univariate analysis, and Cuzick's test for trend.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no decrease in the rate of fatal fetomaternal hemorrhage over the past 25\u00a0years (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.29), despite a decline in overall antepartum deaths (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0049). Fetomaternal hemorrhage accounted for 4.1% (34\/828) of antepartum stillbirths. A higher proportion of these stillbirths occurred at term gestations (74%; 25\/34) compared with other causes (40%; 321\/794; <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0003). Female infants were statistically more likely to be involved than males [odds ratio (OR) 2.33, 95% confidence interval (CI) 1.08\u20135.47, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02). Multiple gestations were up to six times as likely to be affected as singleton pregnancies (OR 6.52, 95% CI 1.67\u201318.50, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Over the past 25\u00a0years there has been no reduction in rates of fatal fetomaternal hemorrhage. Female infants and multiple gestations remain at higher risk of antepartum death from fatal fetomaternal hemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12762","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T18:22:32Z","timestamp":1441218152000},"page":"1354-1358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The contribution of massive fetomaternal hemorrhage to antepartum stillbirth: a 25\u2010year cross\u2010sectional study"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-9021","authenticated-orcid":false,"given":"Bobby D.","family":"O'Leary","sequence":"first","affiliation":[{"name":"UCD Obstetrics &amp; Gynaecology School of Medicine and Medical Science University College Dublin National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-2805","authenticated-orcid":false,"given":"Colin A.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2110-6969","authenticated-orcid":false,"given":"Joan M.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Haematology National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-4678","authenticated-orcid":false,"given":"Paul","family":"Downey","sequence":"additional","affiliation":[{"name":"Department of Histopathology National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-6494","authenticated-orcid":false,"given":"Fionnuala M.","family":"McAuliffe","sequence":"additional","affiliation":[{"name":"UCD Obstetrics &amp; Gynaecology School of Medicine and Medical Science University College Dublin National Maternity Hospital Dublin Ireland"},{"name":"Fetal Medicine Unit National Maternity Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181da7929"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000271212.66040.70"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30490273444.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199706000-00022"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60064-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62233-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01481043"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5817.31"},{"key":"e_1_2_7_10_1","volume-title":"Guidelines for the estimation of fetomaternal haemorrhage","author":"Working Party of the British Committee for Standards in Haematology, Transfusion Taskforce","year":"2009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62310-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90374-8"},{"key":"e_1_2_7_13_1","volume-title":"Perinatal mortality 2009: United Kingdom","author":"Centre for Maternal and Child Enquiries (CMACE)","year":"2011"},{"key":"e_1_2_7_14_1","first-page":"323","article-title":"Massive fetomaternal hemorrhage: Manitoba experience","volume":"83","author":"Almeida V","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610701812181"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90228-9"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12762","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:54:44Z","timestamp":1695549284000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,16]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/aogs.12762"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12762","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,16]]},"assertion":[{"value":"2015-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}