{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:46:05Z","timestamp":1778154365842,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Our aim was to investigate the prognostic value of first\u2010trimester glycosylated hemoglobin (HbA1c) in pregnant women with risk factors for developing gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This is an observational retrospective cohort study conducted at the Department of Obstetrics and Gynecology, University Hospital Bern, Switzerland. We included pregnant women at high risk for <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 208), who had an HbA1c measurement in the first trimester. We compared HbA1c values of women who later developed <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> with those who did not develop <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>. Diagnosis of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> was made on the basis of a 75\u2010g oral glucose tolerance test performed between 24 and 28 weeks of gestation. We further examined the prevalence of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> in relation to the first\u2010trimester HbA1c value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> in our high\u2010risk group was 14.7%. Women who developed <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> had significantly higher first\u2010trimester HbA1c values [5.43 \u00b1 0.31% (36 \u00b1 3 mmol\/mol) vs. 5.23 \u00b1 0.28% (34 \u00b1 3 mmol\/mol); <jats:italic>p<\/jats:italic> = 0.0026]. Moreover, all pregnant women with HbA1c \u22656.0% (42 mmol\/mol) developed <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>, whereas those with &lt;4.5% (26 mmol\/mol) did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women at risk for <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> have higher first\u2010trimester HbA1c levels and values \u22656.0% (42 mmol\/mol) are predictive of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>. This information may be useful for counseling these women and providing appropriate advice on diet and lifestyle modification early in pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12784","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T10:36:28Z","timestamp":1443090988000},"page":"93-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["First\u2010trimester glycosylated hemoglobin in women at high risk for gestational diabetes"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-4064","authenticated-orcid":false,"given":"Sofia","family":"Amylidi","sequence":"first","affiliation":[{"name":"Department for Gynecology and Obstetrics Inselspital University Hospital of Bern and University of Bern Bern 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Inselspital University Hospital of Bern and University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-1584","authenticated-orcid":false,"given":"Daniel","family":"Surbek","sequence":"additional","affiliation":[{"name":"Department for Gynecology and Obstetrics Inselspital University Hospital of Bern and University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-3810","authenticated-orcid":false,"given":"Luigi","family":"Raio","sequence":"additional","affiliation":[{"name":"Department for Gynecology and Obstetrics Inselspital University Hospital of Bern and University of Bern Bern 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