{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:27:27Z","timestamp":1777980447189,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T00:00:00Z","timestamp":1446940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005609","name":"Turun Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Metformin seems to reduce gestational weight gain compared with insulin in women with gestational diabetes (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>). Women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> requiring insulin are more likely to develop abnormal glucose tolerance postpartum than women treated with diet only. In this prospective follow\u2010up study of a randomized clinical trial, we investigated the effect of metformin treatment in women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> on weight gain and glucose tolerance postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> with two or more pathologic glucose values at 2\u2010h 75\u2010g oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) were recruited. Those needing medication to achieve sufficient glycemic control were randomized at 22\u201334 weeks of gestation to either metformin (<jats:italic>n<\/jats:italic> = 110) or insulin (<jats:italic>n<\/jats:italic> = 107) treatment until delivery. A third <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> group (<jats:italic>n<\/jats:italic> = 128) requiring no medication had only diet treatment. Weight, <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> and glycosylated hemoglobin (HbA1c) were determined at 6\u20138 weeks and 1 year postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At least one postpartum visit was attended by 104, 101 and 120 women in the metformin, insulin and diet\u2010only groups, respectively. No significant differences were found in the change of weight, HbA1c or <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> glucose values between the groups during the study (<jats:italic>p<\/jats:italic> \u2265 0.121 in all comparisons). One year postpartum the diet\u2010only group had less impaired glucose tolerance compared with the metformin and insulin groups (7.1%, 19.1% and 15.6%, respectively; overall <jats:italic>p<\/jats:italic> = 0.039) and a lower incidence of diabetes (<jats:italic>p<\/jats:italic> = 0.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short\u2010term metformin therapy does not affect weight, HbA1c or <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> glucose values postpartum compared with insulin or diet\u2010only treatments. Women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> requiring no medication are least likely to develop impaired glucose tolerance or diabetes postpartum.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12788","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T11:52:39Z","timestamp":1444132359000},"page":"79-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The effects of metformin treatment of gestational diabetes on maternal weight and glucose tolerance postpartum \u2013 a prospective follow\u2010up study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9272-2278","authenticated-orcid":false,"given":"Outi","family":"Pellonper\u00e4","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Turku University Hospital and University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7440-2828","authenticated-orcid":false,"given":"Tapani","family":"R\u00f6nnemaa","sequence":"additional","affiliation":[{"name":"Department of Medicine Turku University Hospital and University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8669-0521","authenticated-orcid":false,"given":"Ulla","family":"Ekblad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Turku University Hospital and University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4935-3056","authenticated-orcid":false,"given":"Tero","family":"Vahlberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8950-3103","authenticated-orcid":false,"given":"Kristiina","family":"Tertti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Turku University Hospital and University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2007.03.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707943"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903550659"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60731-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042973"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707193"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02763.x"},{"key":"e_1_2_8_11_1","first-page":"1011","article-title":"Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison","volume":"52","author":"Moore LE","year":"2007","journal-title":"J Reprod Med"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.09.031"},{"key":"e_1_2_8_13_1","first-page":"327","article-title":"Comparison of newborn outcomes in women with gestational diabetes mellitus treated with metformin or insulin: a randomised blinded trial","volume":"4","author":"Mesdaghinia E","year":"2013","journal-title":"Int J Prev Med"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.03.022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064585"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0346"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3324"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2095"},{"key":"e_1_2_8_19_1","unstructured":"Hyv\u00f6nenK.Prevalence and screening for gestational diabetes. 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