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The pooled odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) with 95% confidence intervals were estimated for the association of <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> C677T polymorphism with preterm delivery and placental abruption using random effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 22 studies that met inclusion and exclusion criteria were included in this meta\u2010analysis. Regardless of the genetic model tested we found no statistically significant association of <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> C677T polymorphism with preterm delivery or placental abruption. Funnel plots inspections, Begg's test and Egger's test did not show evidence of publication bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis demonstrated that overall there was no association of <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> C677T polymorphism with preterm delivery or placental abruption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12789","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T13:15:20Z","timestamp":1444137320000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of methylenetetrahydrofolate reductase (<i><scp>MTHFR<\/scp><\/i>) C677T polymorphism with preterm delivery and placental abruption: a systematic review and 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