{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:28:20Z","timestamp":1787585300436,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T00:00:00Z","timestamp":1447286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      There are several published clinical trials of the use of tranexamic acid (\n                      <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>\n                      ) in an obstetric setting, but no consensus on its use or guidelines for management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      The aim of this meta\u2010analysis was to evaluate the effectiveness of\n                      <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>\n                      in reducing blood loss when given prior to cesarean delivery. We performed a systematic search in electronic databases. We included all randomized controlled trials comparing the use of\n                      <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>\n                      prior to cesarean delivery with controls (either placebo or no treatment).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine trials with 2365 women were included in the analysis. Women who received\n                      <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>\n                      had significantly less postpartum blood loss, a lower drop in hemoglobin and a lower incidence of postpartum hemorrhage and severe postpartum hemorrhage compared with controls. Moreover, the number of women who needed additional uterotonic agents was significantly lower in the\n                      <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>\n                      group than in controls. The percentage of women who required blood transfusions at, or immediately after, cesareans was significantly lower in the intervention group than in the controls. There was no difference in the incidence of thromboembolic events in the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Prophylactic\n                      <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>\n                      given before cesarean skin incision in women undergoing cesarean delivery, under spinal or epidural anesthesia, significantly decreases blood loss, including postpartum hemorrhage and severe postpartum hemorrhage, in addition to the standard prophylactic oxytocin given after delivery of the neonate. The effect of\n                      <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>\n                      on thromboembolic events and mortality as well as its use in high\u2010risk women should be investigated further.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.12798","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T17:38:53Z","timestamp":1444757933000},"page":"28-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Tranexamic acid for preventing postpartum blood loss after cesarean delivery: a systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7186-395X","authenticated-orcid":false,"given":"Giuliana","family":"Simonazzi","sequence":"first","affiliation":[{"name":"Department of Medical Surgical Sciences Division of Obstetrics and Prenatal Medicine St Orsola Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-022X","authenticated-orcid":false,"given":"Maria","family":"Bisulli","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences Division of Obstetrics and Prenatal Medicine St Orsola Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0078-2113","authenticated-orcid":false,"given":"Gabriele","family":"Saccone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry School of Medicine University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0342-512X","authenticated-orcid":false,"given":"Elisa","family":"Moro","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences Division of Obstetrics and Prenatal Medicine St Orsola Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7388-0422","authenticated-orcid":false,"given":"Ariela","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Department of Hematology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2854-0239","authenticated-orcid":false,"given":"Vincenzo","family":"Berghella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Maternal\u2010Fetal Medicine Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization (WHO).WHO guidelines for the management of postpartum haemorrhage and retained placenta. Available online at:http:\/\/whqlibdoc.who.int\/publications\/2009\/9789241598514_eng.pdf(accessed 3 November 2014)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-55"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/beog.1999.0060"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00226-6"},{"key":"e_1_2_8_6_1","first-page":"CD001886","article-title":"Anti\u2010fibronolytic use for minimizing perioperative allogeneic blood transfusion","volume":"4","author":"Henry DA","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9193"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta17100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001408010250"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00287-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1268238"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.07.015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.794210"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2593-y"},{"key":"e_1_2_8_15_1","first-page":"459","article-title":"Tranexamic acid in decreasing blood loss during and after caesarean section","volume":"23","author":"Shahid A","year":"2013","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2624-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.941283"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_8_19_1","unstructured":"HigginsJPT AltmanDG SterneJAC.Cochrane handbook for systematic reviews of interventions version 5.1.0 (update March 2011). The Cochrane Collaboration 2011. Available online at:www.cochrane-handbook.org(accessed 5 November 2014)."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.121077"},{"key":"e_1_2_8_21_1","first-page":"CD007872","article-title":"Tranexamic acid for preventing postpartum haemorrhage","volume":"6","author":"Novikova N","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2014.07.748"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12341"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00554669"},{"key":"e_1_2_8_25_1","first-page":"CD010245","article-title":"Tranexamic acid for reducing mortality in emergency and urgent surgery","volume":"1","author":"Perel P","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61015-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4829"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12798","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:27:45Z","timestamp":1695475665000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,12]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/aogs.12798"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12798","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,12]]},"assertion":[{"value":"2015-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}