{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:28:23Z","timestamp":1778862503139,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T00:00:00Z","timestamp":1446940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to evaluate the role of mid\u2010trimester fetal biometry, uterine artery Doppler indices and maternal demographics in prediction of small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted a retrospective cohort study in a single referral center. The study included 23 894 singleton pregnancies scanned between 19 and 24 weeks of gestation. Maternal demographics included age, body mass index and ethnicity. Fetal biometry, birthweight and uterine artery pulsatility index values were converted into centiles. Multivariable logistic regression analysis was performed and the predictive accuracy was assessed using receiver operating characteristic curve analysis. The main outcome measure was prediction of delivery of preterm and term <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates defined as a birthweight in the lowest centile groups (&lt;10th, &lt;5th and &lt;3rd centiles).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal ethnicity, fetal biometry and uterine artery Doppler indices were significantly associated with the risk of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> &lt;5th centile (<jats:italic>p<\/jats:italic> &lt; 0.01). Maternal factors or fetal biometry alone showed poor to moderate performance in prediction of term and preterm <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> &lt;5th centile at a 10% false\u2010positive rate. Uterine artery pulsatility index alone was able to predict 25, 60 and 77% of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> &lt;5th centile delivering at &gt;37, &lt;37 and &lt;32 weeks of gestation respectively at a 10% false\u2010positive rate; maternal factors, fetal biometry and uterine artery Doppler combined detected 40, 66 and 89% of term, preterm and very preterm <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> &lt;5th centile at a 10% false\u2010positive rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Second\u2010trimester screening can identify the majority of pregnancies at high risk of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> birth and showed a higher performance for earlier gestational ages at birth and lower birthweight centiles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12804","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T01:46:41Z","timestamp":1444960001000},"page":"238-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Mid\u2010pregnancy fetal biometry, uterine artery Doppler indices and maternal demographic characteristics: role in prediction of small\u2010for\u2010gestational\u2010age birth"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-9383","authenticated-orcid":false,"given":"Alessandra","family":"Familiari","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Academic Department of Obstetrics and Gynaecology St George's University of London London 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