{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:19:21Z","timestamp":1770697161833,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Preoperative knowledge of myometrial invasion in endometrial cancer is important for surgical planning. This study aimed to assess the diagnostic efficiency of two\u2010dimensional (2D) and three\u2010dimensional (3D) transvaginal ultrasonography (<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content>) with and without saline infusion (<jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content>) and magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) for assessment of myometrial invasion in endometrial cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>110 women with atypical endometrial hyperplasia or endometrial adenocarcinoma underwent preoperative 2D\u2010 and 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> with and without <jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Offline 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> measurement was performed of the minimal tumor\u2010free margin in relation to myometrial thickness expressed as deep (\u226550%) myometrial invasion and subjective impression of cervix involvement. The quality of images was also evaluated. Diagnostic efficiencies were calculated for myometrial and cervical involvement for each method. The pathologist's final diagnosis served as the reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For myometrial involvement, <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> showed greater accuracy than 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> or 2D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> (83, 71 and 75%, respectively). The efficiency of 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> was not superior to 2D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> and did not improve with <jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content>. The sensitivities of 2D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> and 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> were similar to that of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, and the efficiency of 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> improved when volumes of inadequate quality (39%) were excluded. For evaluating cervical involvement, the accuracy of 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> was 85%, comparable to the results of 2D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> (80%) and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (85%). The results did not improve when saline was added.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> or 3D\u2010<jats:styled-content style=\"fixed-case\">SIS<\/jats:styled-content> was not more efficient than 2D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> for assessment of myometrial invasion in endometrial cancer. 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> assessment without 2D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> was impeded by difficulties in obtaining 3D\u2010<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> volumes of sufficient quality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12806","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T14:23:07Z","timestamp":1445350987000},"page":"55-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Assessment of myometrial invasion in endometrial cancer using three\u2010dimensional ultrasound and magnetic resonance imaging"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-0121","authenticated-orcid":false,"given":"Julie W.","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2577-7903","authenticated-orcid":false,"given":"Margit","family":"Dueholm","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7808-908X","authenticated-orcid":false,"given":"Estrid S.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Histopathology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4279-7188","authenticated-orcid":false,"given":"Edward","family":"Marinovskij","sequence":"additional","affiliation":[{"name":"The MRI Center Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-2172","authenticated-orcid":false,"given":"Erik","family":"Lundorf","sequence":"additional","affiliation":[{"name":"The MRI Center Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5817-4092","authenticated-orcid":false,"given":"Gitte","family":"\u00d8rtoft","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"MirzaMR J\u00f8rgensenM LarsenS HenrikK KahnR FranzmannMB et\u00a0al.Dansk Gyn\u00e6kologisk Cancer Gruppe: Retningslinier for Visitation Diagnostik Behandling og Kontrol af Cancer Corporis Uteri. 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