{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:02:53Z","timestamp":1769346173986,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,3]],"date-time":"2016-01-03T00:00:00Z","timestamp":1451779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"King's College Hospital Charity","award":["230729"],"award-info":[{"award-number":["230729"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fetal growth restriction (<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>) is associated with poor perinatal outcomes. Screening and prevention tools for <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>, such as uterine artery Doppler imaging and aspirin, underperform in high\u2010risk groups, compared with general antenatal populations. There is a paucity of sensitive screening tests for the early prediction of <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> in high\u2010risk pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a prospective observational study based in a dedicated antenatal hypertension clinic at a tertiary <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> hospital. We assessed maternal demographic and central hemodynamic variables as predictors for <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> in a group of women at high risk for placental insufficiency due to chronic hypertension (<jats:italic>n<\/jats:italic> = 55) or a history of hypertension in a previous pregnancy (<jats:italic>n<\/jats:italic> = 71). Outcome variables were birthweight z\u2010score as well as development of <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> (defined as birthweight below the 5th or 3rd centile). Maternal hemodynamics were assessed using a noninvasive transthoracic bioreactance monitor (Cheetah <jats:styled-content style=\"fixed-case\">NICOM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean gestation at presentation was 13.6 (range: 8.5\u201319.5) weeks. Sixteen women delivered babies below the 5th centile. Ten of these were below the 3rd centile. Independent predictors of birthweight z\u2010score were body surface area, peripheral vascular resistance and white ethnicity (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.26, <jats:italic>p<\/jats:italic> &lt; 0.0001). Independent predictors of <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> were maternal height and cardiac output. The area under the receiver operator characteristic curve for prediction of <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> was 0.915 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.859\u20130.972) and 0.9079 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.823\u20130.990) for <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> below the 5th and 3rd centiles, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In women with chronic hypertension or a history of hypertension in a previous pregnancy, maternal size and cardiac output at booking provide a sensitive screening tool for <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12823","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T15:06:44Z","timestamp":1448377604000},"page":"329-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-5560","authenticated-orcid":false,"given":"Daniel","family":"Stott","sequence":"first","affiliation":[{"name":"Division of Women's Health King's College Hospital Antenatal Hypertension Clinic London 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