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This study aimed to investigate health outcomes in women aged 18\u201324 years with biopsy\u2010confirmed <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A retrospective cohort study of Western Australian women aged 18\u201324 years diagnosed with <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 on cervical biopsy from 1 January 2001 to 31 December 2010. Women who had not received treatment at \u22654 months following <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 diagnosis were classified as managed \u2018conservatively\u2019. Subsequent cervical cytology and\/or biopsy test results were used to report lesion regression (absence of dysplasia or an epithelial lesion of lower grade than <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2) and disease persistence (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 or <jats:styled-content style=\"fixed-case\">ACIS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up data were available for 2417 women of whom 924 (38.2%) were \u2018conservatively\u2019 managed. In all, 152 (16.4%) conservatively managed women had a lesion more severe than <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 detected within 24 months of initial diagnosis, of which 144 were <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 and eight were <jats:styled-content style=\"fixed-case\">ACIS<\/jats:styled-content>. There was no statistically significant association between rates of regression and patient age, Socio\u2010economic Indexes for Areas or Accessibility\/Remoteness Index of Australia indices. The 2\u2010year regression rate for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 was estimated to be 59.5% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.5\u20130.6) in this cohort of women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conservatively managed young women with <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 there was a high rate of spontaneous disease regression. Thus, excisional or ablative treatments may be avoided in selected patients who receive appropriate counseling and who are able to comply with more intensive and prolonged follow\u2010up requirements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12835","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T11:48:34Z","timestamp":1449748114000},"page":"291-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Spontaneous regression of <scp>CIN<\/scp>2 in women aged 18\u201324 years: a retrospective study of a state\u2010wide population in Western Australia"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-1044","authenticated-orcid":false,"given":"Aime","family":"Munro","sequence":"first","affiliation":[{"name":"Institute of Health Research University of Notre Dame Australia Fremantle WA Australia"},{"name":"St John of God Hospital Bendat Family Comprehensive Cancer Centre Subiaco WA Australia"},{"name":"Centre for Population Health Research Curtin University Bentley WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8951-8572","authenticated-orcid":false,"given":"Rhys G.","family":"Powell","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research Curtin University Bentley WA Australia"},{"name":"School of Medicine University of Notre Dame Australia Fremantle WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-9232","authenticated-orcid":false,"given":"Paul","family":"A. 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