{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:13:33Z","timestamp":1762161213695,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to investigate the association between Toll\u2010like receptor 2 (<jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic>) gene polymorphisms and human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>)\u2010related cervical neoplasia in Korean women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Peripheral blood samples collected from 127 patients with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010related cervical neoplasia and 175 healthy women were genotyped for the <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> \u221216934, +1350, intron1, and 3\u2032 untranslated region (<jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content>) polymorphisms using the polymerase chain reaction and restriction fragment length polymorphism method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> \u221216934 A\/A, intron1 A\/A, and +1350 T\/C genotypes were more frequent in patients than in controls [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) = 2.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.302\u20133.475, <jats:italic>p<\/jats:italic> = 0.002; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.9, 95% CI = 1.168\u20133.169, <jats:italic>p<\/jats:italic> = 0.010; and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.9, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.211\u20133.123, <jats:italic>p<\/jats:italic> = 0.006, respectively]. The frequencies of the <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> + 1350 C and 3\u2032<jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content> G alleles were also higher in patients (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.0, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.236\u20133.121, <jats:italic>p<\/jats:italic> = 0.004 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.005\u20133.076, <jats:italic>p<\/jats:italic> = 0.046, respectively). The genotype frequencies of <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> \u221216934 A\/A and intron1 A\/A increased with increasing oncogenic risk of the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotype, as follows. low\u2010risk type &lt; high\u2010risk type &lt; <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u201016 and\/or <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u201018 type (<jats:italic>p<\/jats:italic> = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study provides the first evidence that <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> gene polymorphisms are associated with high\u2010risk type <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010related cervical neoplasia and may play an important role in susceptibility to <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection. Further large\u2010scale and functional studies are needed to confirm the role of <jats:italic><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2<\/jats:italic> gene polymorphisms in <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010related cervical neoplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12895","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T12:29:49Z","timestamp":1458304189000},"page":"829-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Toll\u2010like receptor 2 gene polymorphisms in Korean women with human papillomavirus\u2010related cervical neoplasia"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-1611","authenticated-orcid":false,"given":"Jin Hwi","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Key","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Young","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Gyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Sup","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380703"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04956-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/90609"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00202.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2541"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.050"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-17"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02066.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.07.307"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810390881"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2012.08.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2013.22"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1337.028"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-1932-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-013-0220-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060513483398"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2011.1427"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0607-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1695-8"},{"key":"e_1_2_8_22_1","first-page":"1","article-title":"Biological agents: a review of human carcinogens","volume":"100","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Humans"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.3186"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5629"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-012-2059-9"},{"key":"e_1_2_8_26_1","first-page":"67","article-title":"TLR2 haplotypes in the susceptibility to and severity of Chlamydia trachomatis infections in Dutch women","volume":"45","author":"Karimi O","year":"2009","journal-title":"Drugs Today (Barc)"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2010.06.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis922"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01008.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425910392934"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.12895","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.12895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:22:36Z","timestamp":1695489756000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.12895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/aogs.12895"],"URL":"https:\/\/doi.org\/10.1111\/aogs.12895","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"type":"print","value":"0001-6349"},{"type":"electronic","value":"1600-0412"}],"subject":[],"published":{"date-parts":[[2016,4,18]]},"assertion":[{"value":"2015-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}