{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:53:21Z","timestamp":1773928401256,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Decision\u2010making on embryo disposition is a source of distress and is subject to change over time. This paper analyzes the willingness of couples undergoing in vitro fertilization to donate cryopreserved embryos for research from 15 days after embryo transfer to 12 months later, taking into account the influence of psychosocial, demographic, and reproductive factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Prospective longitudinal study, with 74 heterosexual couples undergoing in vitro fertilization in a public fertility centre in Portugal, recruited between 2011 and 2012. Participants were evaluated twice: 15 days after embryo transfer and 12 months later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant decrease in patients' willingness to donate embryos for research over time was observed [86.5% to 73.6%; relative risk (RR) = 0.85; 95% CI 0.76\u20130.95]. A higher education level (&gt;12 years) [adjusted RR (RR<jats:sub>adj<\/jats:sub>) = 0.79; 95% CI 0.64\u20130.96], considering research on human embryos to be important (vs. very important) (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content><jats:sub>adj<\/jats:sub> = 0.59; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.39\u20130.85) and practicing a religion less than once a month (vs. at least once a month) (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content><jats:sub>adj<\/jats:sub> = 0.73; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.53\u20131.00) seemed associated with unwillingness to donate embryos for research over time. Change towards non\u2010donation happened mainly among couples who first considered that it was better to donate than wasting the embryos. Change towards donation occurred mostly among those stating that their priority at time 1 was to have a baby and who became pregnant in the meantime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Quality of care guided by patients' characteristics, values, preferences, and needs calls for considering the factors and reasons underlying couples' willingness to donate embryos for research over time as a topic in psychosocial guidelines for infertility and medically assisted reproductive care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12900","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T02:48:21Z","timestamp":1458614901000},"page":"912-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Couples' willingness to donate embryos for research: a longitudinal study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-0347","authenticated-orcid":false,"given":"Catarina","family":"Samorinha","sequence":"first","affiliation":[{"name":"EPIUnit (UID\/DTP\/04750\/2013), Institute of Public Health University of Porto Porto Portugal"},{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health University of Porto Medical School Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-4871","authenticated-orcid":false,"given":"Milton","family":"Severo","sequence":"additional","affiliation":[{"name":"EPIUnit (UID\/DTP\/04750\/2013), Institute of Public Health University of Porto Porto Portugal"},{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health University of Porto Medical School Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8554-7619","authenticated-orcid":false,"given":"Helena","family":"Machado","sequence":"additional","affiliation":[{"name":"Centre for Social Studies University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-7445","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"School of Psychology University of Minho Braga Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1828-8642","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"de Freitas","sequence":"additional","affiliation":[{"name":"EPIUnit (UID\/DTP\/04750\/2013), Institute of Public Health University of Porto Porto Portugal"},{"name":"Centre for Research and Studies in Sociology University Institute of Lisbon Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-8648","authenticated-orcid":false,"given":"Susana","family":"Silva","sequence":"additional","affiliation":[{"name":"EPIUnit (UID\/DTP\/04750\/2013), Institute of Public Health University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60686-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg265"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.11.006"},{"key":"e_1_2_9_5_1","unstructured":"ESHRE Psychology and Counselling Guideline Development Group Routine.Psychosocial care in infertility and medically assisted reproduction \u2013 a guide for fertility staff.2015. 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