{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:57:35Z","timestamp":1790614655888,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto de Salud Carlos III in Spain","award":["CM09\/00213"],"award-info":[{"award-number":["CM09\/00213"]}]},{"name":"Instituto de Salud Carlos III in Spain","award":["PI10\/01308"],"award-info":[{"award-number":["PI10\/01308"]}]},{"name":"Instituto de Salud Carlos III in Spain","award":["PI15\/00344"],"award-info":[{"award-number":["PI15\/00344"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to evaluate, in women with preterm prelabor rupture of membranes (<jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content>), the impact on short\u2010term neonatal outcome of microbial invasion of the amniotic cavity (<jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content>), intra\u2010amniotic inflammation (<jats:styled-content style=\"fixed-case\">IAI<\/jats:styled-content>), and the microorganisms isolated in women with <jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content>, when gestational age is taken into account.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Prospective cohort study. We included women with <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> (22.0\u201334.0 weeks of gestation) with available information about <jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IAI<\/jats:styled-content> and short\u2010term neonatal outcome. <jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content> was defined as positive aerobic\/anaerobic\/genital <jats:italic>Mycoplasma<\/jats:italic> culture in amniotic fluid. Definition of <jats:styled-content style=\"fixed-case\">IAI<\/jats:styled-content> was based on interleukin\u20106 levels in amniotic fluid. Main outcome measures were Apgar score &lt;7 at 5 min, umbilical artery <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> \u22647.0, days in the neonatal intensive care unit, and composite neonatal morbidity, including any of the following: intraventricular hemorrhage grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>, respiratory distress syndrome, early\u2010onset neonatal sepsis, periventricular leukomalacia, necrotizing enterocolitis, and fetal or neonatal death. Labor was induced after 32.0 weeks if lung maturity was confirmed; and otherwise after 34.0 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IAI<\/jats:styled-content> were found in 38% (72\/190) and 67% (111\/165), respectively. After adjustment for gestational age at delivery, no differences in short\u2010term neonatal outcome were found between women with either <jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IAI<\/jats:styled-content>, compared with the non\u2010infection\/non\u2010inflammation (\u201cNo\u2010<jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content>\/No\u2010<jats:styled-content style=\"fixed-case\">IAI<\/jats:styled-content>\u201d) group. Furthermore, short\u2010term neonatal outcome did not differ between the <jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content> caused by <jats:italic>Ureaplasma<\/jats:italic> spp. group, the <jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content> caused by other microorganisms group and the \u201cNo\u2010<jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content>\/No\u2010<jats:styled-content style=\"fixed-case\">IAI<\/jats:styled-content>\u201d group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gestational age at delivery seems to be more important for short\u2010term neonatal outcome than <jats:styled-content style=\"fixed-case\">MIAC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IAI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12905","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:09:38Z","timestamp":1460311778000},"page":"926-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Gestational age is more important for short\u2010term neonatal outcome than microbial invasion of the amniotic cavity or intra\u2010amniotic inflammation in preterm prelabor rupture of membranes"],"prefix":"10.1111","volume":"95","author":[{"given":"Adriano","family":"Rodr\u00edguez\u2010Trujillo","sequence":"first","affiliation":[{"name":"BCNatal \u2013 Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de Deu Fetal i+D Fetal Medicine Research Center IDIBAPS University of Barcelona Barcelona 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