{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:59:21Z","timestamp":1790690361989,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005036","name":"Universitetet i Bergen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Centiles of middle cerebral artery pulsatility index and cerebroplacental ratio are useful for predicting adverse perinatal outcomes. A \u2018conditional centile\u2019 is conditioned by a previous measurement reflecting degree of individual change over time. Here we test whether such centiles are independent predictors and whether their combination improves prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This prospective longitudinal study included 220 pregnant women diagnosed with or at risk of having a small\u2010for\u2010gestational\u2010age fetus. Serial Doppler measurements of the umbilical artery and middle cerebral artery pulsatility indexs were used to calculate cerebroplacental ratio. Preterm birth, operative delivery due to fetal distress, admission to neonatal intensive care unit, 5\u2010min Apgar score &lt;7, newborn hypoglycemia, and perinatal mortality were considered adverse outcomes. Possible associations were analyzed by log\u2010binomial regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serial Doppler measurements of the middle cerebral artery were available in 207 participants and cerebroplacental ratio in 205. Conditional centiles \u22645 and \u226410 for both middle cerebral artery pulsatility index and cerebroplacental ratio were associated with increased risk for adverse perinatal outcomes. However, only the combination of cerebroplacental ratio centile and conditional centile \u226410 showed a better performance in the prediction of operative delivery due to fetal distress (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.032), admission to neonatal intensive care unit (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.048), and the combined variable \u201cany adverse outcomes\u201d (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.034) compared with the use of centile \u226410 alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conditional centile for middle cerebral artery pulsatility index and cerebroplacental ratio \u22645 and \u226410 are associated with adverse perinatal outcomes. When adding conditional centile to conventional centile for cerebroplacental ratio, the prediction improved compared with the use of conventional centile alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12912","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T13:04:37Z","timestamp":1461243877000},"page":"690-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of conditional centiles of middle cerebral artery pulsatility index and cerebroplacental ratio in the prediction of adverse perinatal outcomes"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-1702","authenticated-orcid":false,"given":"Henriette O.","family":"Karlsen","sequence":"first","affiliation":[{"name":"Research Group for Pregnancy Fetal Development and Birth Department of Clinical Science University of Bergen Bergen 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