{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:07:42Z","timestamp":1790129262372,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The risk of morcellation of occult uterine leiomyosarcomas (<jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content>) during laparoscopic procedures has been under scrutiny over recent years. The objective of this study was to assess the operative treatment performed in women with uterine <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content> in Norway in 2000\u20132012, including the number of morcellated <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Retrospective nationwide cohort study. The study participants were all women with histopathologically verified uterine <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content> in Norway during 2000\u20132012. The data were collected from the Cancer Registry of Norway, National Patient Registry and medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 212 women diagnosed with uterine <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content> in Norway in 2000\u20132012. Mean age at time of diagnosis was 58.1 years (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> \u00b1 12.5). The most frequent symptom in women suffering from <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content> was abnormal uterine bleeding [110\/212 (51.9%)]. <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content> was histopathologically verified in 49\/212 (23.1%) preoperatively. In 48\/212 (22.6%), a malignant condition was suspected and they were treated accordingly. In 115\/212 (54.2%), malignancy was not suspected at time of surgery and the women were treated according to the treatment protocol for fibroids. In only four patients was tissue retrieval by power morcellation conducted, accounting for 1.9% of all <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content> cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In more than 50% of women suffering from <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content>, a malignant diagnosis was not confirmed or suspected prior to surgery. In our material, power morcellation of <jats:styled-content style=\"fixed-case\">LMS<\/jats:styled-content> has not lead to reduced survival. We suggest that power morcellators may be used in surgical treatment of selected cases of premenopausal women with symptomatic, presumed benign uterine leiomyomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.12930","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T22:21:47Z","timestamp":1464214907000},"page":"984-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Uterine leiomyosarcoma \u2013 incidence, treatment, and the impact of morcellation. A nationwide cohort study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1474-0563","authenticated-orcid":false,"given":"Mette","family":"Skorstad","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Vestfold Hospital Tonsberg Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Gynecology Royal Surrey Hospital Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit","family":"Lieng","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"AAGL.Morcellation during uterine tissue extraction [Internet].2014. Available online at:http:\/\/www.aagl.org\/wp-content\/uploads\/2014\/05\/Tissue_Extraction_TFR.pdf(updated May 2014 cited January 2016)."},{"key":"e_1_2_10_3_1","first-page":"399","article-title":"The epidemiology of sarcomas of the uterus","volume":"76","author":"Harlow BL","year":"1986","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_10_4_1","first-page":"CD004638","article-title":"Minimally invasive surgical techniques versus open myomectomy for uterine fibroids","volume":"10","author":"Bhave Chittawar P","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_5_1","unstructured":"NICE.Laparoscopic techniques for hysterectomy. NICE interventional procedure guidance [IPG239] [Internet]2007. Available online at:www.nice.org.uk\/ipg239(updated 14 January 2012 cited 8 February 2016)."},{"key":"e_1_2_10_6_1","unstructured":"FDA Release: FDA discourages use of laparoscopic power morcellation for removal of uterus or uterine fibroids [Internet].2014. Available online at:http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm393689.htm (updated 10 October 2014 cited 8 February 2016)."},{"key":"e_1_2_10_7_1","unstructured":"Regional Committee for Medical and Health Research Ethics (REK).2014\/2315 Diagnostikk og behandling av uterine leiomyosarkomer i Norge i perioden 2000\u20132012 [Internet].2015. 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Available online at:http:\/\/www.acog.org\/About-ACOG\/News-Room\/Statements\/2015\/ACOG-Statement-on-FDA-Regulation-of-Morcellation(updated 8 December 2015 cited 8 February 2016)."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001157"},{"key":"e_1_2_10_19_1","unstructured":"SGO.Statement of the Society of Gynecologic Oncology to the Food and Drug Administration's Obstetrics and Gynecology Medical Devices Advisory Committee Concerning Safety of Laparoscopic Power Morcellation [Internet].2014. 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