{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:59:18Z","timestamp":1789156758740,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Human papillomavirus (\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      ) infection is an objective marker with a high sensitivity for finding cervical dysplasia. The objective of the current study is to investigate whether\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      testing, combined with liquid\u2010based cytology, is reliable as a test of cure after the loop electrical excision procedure (\n                      <jats:styled-content style=\"fixed-case\">LEEP<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">LEEP<\/jats:styled-content>\n                      was performed in 330 women for excision of cervical dysplasia. Follow up consisted of\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      testing and liquid\u2010based cytology at six, 12, and 36\u00a0months after treatment. Patients with negative co\u2010testing after 6\u00a0months were re\u2010examined after 3\u00a0years. Patients who tested positive for high\u2010risk\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      and\/or dysplasia were followed up 12\u00a0months postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 6\u00a0months, the co\u2010testing was double negative in 169 of 260 tested cases (65%). A positive high\u2010risk\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      test (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040) was associated with cytological abnormalities (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). After 3\u00a0years, 227 of 275 examined cases (83%) co\u2010tested negative, including 154 patients who had already tested negative at 6\u00a0months and 37 cases with viral clearance at 12\u00a0months. Of 26 patients with high\u2010risk\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      at the 3\u2010year follow up, six had\n                      <jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>\n                      findings on liquid\u2010based cytology, but neither\n                      <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>\n                      lesions nor glandular atypia or cervical cancer was found. A negative high\u2010risk\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      test showed a negative predictive value for\n                      <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>\n                      of 100% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      99.8\u2013100%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Negative co\u2010testing 6\u00a0months after\n                      <jats:styled-content style=\"fixed-case\">LEEP<\/jats:styled-content>\n                      can be considered a reliable test of cure as 3\u2010year follow\u2010up results are consistent with neither\n                      <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>\n                      or cancer.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.12960","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T10:16:53Z","timestamp":1470910613000},"page":"1251-1257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Follow up with\n                    <scp>HPV<\/scp>\n                    test and cytology as test of cure, 6\u00a0months after conization, is reliable"],"prefix":"10.1111","volume":"95","author":[{"given":"Katrin Christine","family":"Asciutto","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"Henic","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Sk\u00e5ne University 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