{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:47:39Z","timestamp":1791406059452,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The goal of this study was to assess the sensitivity of different preoperative diagnostic tools used in women with uterine leiomyosarcomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Retrospective cohort study of all women with verified uterine leiomyosarcoma in Norway in the period 2000 to 2012. Data were collected from the Cancer Registry of Norway and medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 212 women diagnosed with uterine leiomyosarcoma in the 13\u2010year period. Histopathological examinations by fractional curettage or endometrial biopsies verified malignancy in 55\/142 (38.7%). <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> suggested malignancy in 45\/55 (81%) of the examinations. <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> evaluations indicated suspected malignancy in 64\/107 women (59.8%). Biomarkers had low sensitivity for leiomyosarcoma, but suggested more advanced stage disease when high values were detected. Stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> disease was present in 53.1% versus 25.5% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) of women with CA 125 values above 35\u00a0kU\/L, compared with women with normal CA 125 values. In 115\/212 (54.2%), leiomyosarcoma was only diagnosed postoperatively by histopathological examination of the removed specimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative diagnostic modalities appear to have low sensitivity for differentiating leiomyosarcoma from fibroids. In Norway, approximately 54% of uterine leiomyosarcoma are unidentified before surgery. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> evaluation was the imaging modality with the greatest sensitivity in identifying leiomyosarcoma preoperatively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13008","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T13:59:13Z","timestamp":1472219953000},"page":"1228-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Preoperative evaluation in women with uterine leiomyosarcoma. 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