{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:29:06Z","timestamp":1779370146049,"version":"3.53.0"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009123","name":"Norges Teknisk-Naturvitenskapelige Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We evaluated colposcopy in the routine diagnostic workup of women with abnormal cervical cytology, as well as the diagnostic value of endocervical curettage material and biopsies taken from colposcopy\u2010positive and colposcopy\u2010negative quadrants of the cervix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This cross\u2010sectional study included 297 nonpregnant women with abnormal cervical cytology and no prior treatment for cervical dysplasia or cancer. All women underwent gynecological examination, colposcopy, endocervical curettage, and had cervical biopsies taken. Colposcopy was considered satisfactory if the squamocolumnar junction was fully visible, and biopsies were taken from all four quadrants of the cervix, regardless of colposcopy results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 130 of the women in our study had satisfactory colposcopy results and were diagnosed with cervical intraepithelial neoplasia grade 2 or worse (CIN2+), 61% via a colposcopy\u2010positive biopsy and 39% via a colposcopy\u2010negative biopsy. Eighty\u2010seven of them had positive colposcopy results, but CIN2+ was histologically verified from colposcopy\u2010positive biopsies in 91% (<jats:italic>n<\/jats:italic>\u00a0=\u00a079) and from colposcopy\u2010negative biopsies in 9% (<jats:italic>n<\/jats:italic>\u00a0=\u00a08). The remaining 43 women with CIN2+ had negative colposcopy findings, so their diagnosis was verified in colposcopy\u2010negative biopsies. The sensitivity of colposcopy alone to detect CIN2+ was 61% (95% CI 52\u201369).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the present study, colposcopy was not a stand\u2010alone diagnostic method. Colposcopy\u2010negative biopsies had a clear additive value, identifying a substantial proportion of women with both positive and negative colposcopy results with treatment\u2010worthy cervical dysplasia. Endocervical curettage material had little diagnostic value in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13009","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T14:42:41Z","timestamp":1472222561000},"page":"1258-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Colposcopy and additive diagnostic value of biopsies from colposcopy\u2010negative areas to detect cervical dysplasia"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0688-8031","authenticated-orcid":false,"given":"Ingrid","family":"Baasland","sequence":"first","affiliation":[{"name":"Department of Public Health and General Practice Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9904-3195","authenticated-orcid":false,"given":"Bj\u00f8rn","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"},{"name":"Department of Laboratory Medicine Children's and Women's Health Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-0539","authenticated-orcid":false,"given":"Christina","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Children's and Women's Health Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Pathology and Medical Genetics St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-8779","authenticated-orcid":false,"given":"Marit","family":"Valla","sequence":"additional","affiliation":[{"name":"Department of Public Health and General Practice Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Pathology and Medical Genetics St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-4336","authenticated-orcid":false,"given":"P\u00e5l R.","family":"Romundstad","sequence":"additional","affiliation":[{"name":"Department of Public Health and General Practice Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80244-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318254f90c"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00895.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25470"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000220505.18525.85"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.05.033"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.02.065"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-014-0739-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.9948"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3181fb4547"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000458"},{"key":"e_1_2_8_13_1","unstructured":"Norsk gynekologisk forening.Veileder i gynekologisk onkologi 2009: Premaligne lidelser i cervix: Norsk gynekologisk forening [Coaching in gynecological oncology 2009: Premalign disorders of the cervix: Norwegian gynecological association].2009. Available online at:http:\/\/legeforeningen.no\/Fagmed\/Norsk-gynekologisk-forening\/Veiledere\/veileder-i-gynekologisk-onkologi-2009\/premaligne-lidelser-i-cervix\/(accessed January 15 2015)."},{"key":"e_1_2_8_14_1","volume-title":"Pathology and genetics of tumours of the breast and female genital organs (World Health Organization classification of tumours; 5)","author":"Tavassoli FA","year":"2003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.048"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00082-9"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.13009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.13009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:23:43Z","timestamp":1695500623000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,19]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/aogs.13009"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13009","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,19]]},"assertion":[{"value":"2016-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}