{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:49:59Z","timestamp":1787064599681,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tampere University Hospital Competitive Funding","award":["9R033"],"award-info":[{"award-number":["9R033"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      In randomized studies, testing for high\u2010risk (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ) human papillomavirus (hrHPV) has been more sensitive than conventional cytology in detecting cervical intraepithelial neoplasia (\n                      <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n                      ). The aim of this study was to evaluate the performance of\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      testing in the setting of an organized routine screening program.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      Since 2012, 35\u2010 to 60\u2010year\u2010old women living in the city of Tampere have been screened with the Abbott RealTime hrHPV test.\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      \u2010negative women are referred to the next screening round in five years.\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      \u2010positive women are triaged with conventional cytology, and women with at least low\u2010grade squamous intraepithelial lesion (\n                      <jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>\n                      <jats:sup>+<\/jats:sup>\n                      ) are referred to colposcopy. The remaining\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      \u2010positive women are referred for re\u2010testing after 12\u00a0months, and then all\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      \u2010positive women are referred to colposcopy. The data from the last cohort with cytological screening (screened in 2011) is presented for comparison.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total 5637 (70%) women attended the first round of\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      screening, and 369 were\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      \u2010positive. Of them, 54 women\n                      <jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>\n                      <jats:sup>+<\/jats:sup>\n                      were referred to colposcopy, resulting in 16\n                      <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n                      2\n                      <jats:sup>+<\/jats:sup>\n                      lesions found. Of the remaining\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      \u2010positive women, 66% were still positive one year later, and were referred to colposcopy, with 18 additional\n                      <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n                      2\n                      <jats:sup>+<\/jats:sup>\n                      lesions found. The attendance rate to the last round of cytological screening was 71% (5814 women). Sixty\u2010four women with\n                      <jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>\n                      <jats:sup>+<\/jats:sup>\n                      cytology were referred to colposcopy, and 11\n                      <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n                      2\n                      <jats:sup>+<\/jats:sup>\n                      lesions were found. Of the 777 women with borderline cytology and scheduled for reflex screening in the following year, 109 (19%) had\n                      <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                      <jats:sup>+<\/jats:sup>\n                      , and 57 underwent colposcopy, resulting in six additional\n                      <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n                      2\n                      <jats:sup>+<\/jats:sup>\n                      lesions found. The total detection rate of\n                      <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n                      2\n                      <jats:sup>+<\/jats:sup>\n                      was significantly higher in the\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      \u2010screened cohort (6.0\/1000 vs. 2.9\/1000,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.015). However, the total colposcopy rate was 4% vs. 2%, respectively (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Human papillomavirus testing also seems to be more sensitive than cytology in detecting\n                      <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n                      2\n                      <jats:sup>+<\/jats:sup>\n                      lesions in the setting of a routine organized screening program, besides in the context of randomized trials. The problem of an increased colposcopy rate needs to be addressed in the future.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.13013","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T10:52:42Z","timestamp":1472899962000},"page":"1220-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Human papillomavirus test with cytology triage in organized screening for cervical cancer"],"prefix":"10.1111","volume":"95","author":[{"given":"Olga","family":"Veijalainen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Vaasa Central Hospital Vaasa Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Kares","sequence":"additional","affiliation":[{"name":"Pathology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Kujala","sequence":"additional","affiliation":[{"name":"Pathology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Tirkkonen","sequence":"additional","affiliation":[{"name":"Pathology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Vuento","sequence":"additional","affiliation":[{"name":"Microbiology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kholov\u00e1","sequence":"additional","affiliation":[{"name":"Pathology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Luukkaala","sequence":"additional","affiliation":[{"name":"Science Center Pirkanmaa Hospital District and School of Health Sciences University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Osuala","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Municipal Hospital of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"M\u00e4enp\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tampere University Hospital and School of Medicine University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<59::AID-IJC12>3.0.CO;2-N"},{"key":"e_1_2_8_4_1","unstructured":"Finnish Cancer Register.Mean annual numbers of new cancer cases in 1967\u20102013 by primary site and period FEMALES. 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