{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:38:07Z","timestamp":1791574687987,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["2013\u20102429"],"award-info":[{"award-number":["2013\u20102429"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["20130156"],"award-info":[{"award-number":["20130156"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>An increased risk of preterm birth in women with joint hypermobility syndrome or Ehlers\u2013Danlos syndrome is suspected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this nationwide cohort study from 1997 through 2011, women with either joint hypermobility syndrome or Ehlers\u2013Danlos syndrome or both disorders were identified through the Swedish Patient Register, and linked to the Medical Birth Register. Thereby, 314 singleton births to women with joint hypermobility syndrome\/Ehlers\u2013Danlos syndrome before delivery were identified. These births were compared with 1\u00a0247\u00a0864 singleton births to women without a diagnosis of joint hypermobility syndrome\/Ehlers\u2013Danlos syndrome. We used logistic regression, adjusted for maternal age, smoking, parity, and year of birth, to calculate adjusted odds ratios for adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal joint hypermobility syndrome\/Ehlers\u2013Danlos syndrome was not associated with any of our outcomes: preterm birth (adjusted odds ratio\u00a0=\u00a00.6, 95% confidence interval 0.3\u20131.2), preterm premature rupture of membranes (adjusted odds ratio\u00a0=\u00a00.8; 95% confidence interval 0.3\u20132.2), cesarean section (adjusted odds ratio\u00a0=\u00a00.9, 95% confidence interval 0.7\u20131.2), stillbirth (adjusted odds ratio\u00a0=\u00a01.1, 95% confidence interval 0.2\u20137.9), low Apgar score (adjusted odds ratio\u00a0=\u00a01.6, 95% confidence interval 0.7\u20133.6), small for gestational age (adjusted odds ratio\u00a0=\u00a00.9, 95% confidence interval 0.4\u20131.8) or large for gestational age (adjusted odds ratio\u00a0=\u00a01.2, 95% confidence interval 0.6\u20132.1). Examining only women with Ehlers\u2013Danlos syndrome (<jats:italic>n<\/jats:italic>\u00a0=\u00a062), we found a higher risk of induction of labor (adjusted odds ratio\u00a0=\u00a02.6; 95% confidence interval 1.4\u20134.6) and amniotomy (adjusted odds ratio\u00a0=\u00a03.8; 95% confidence interval 2.0\u20137.1). No excess risks for adverse pregnancy outcome were seen in joint hypermobility syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with joint hypermobility syndrome\/Ehlers\u2013Danlos syndrome do not seem to be at increased risk of adverse pregnancy outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13043","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T15:42:50Z","timestamp":1476459770000},"page":"114-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Pregnancy outcome in joint hypermobility syndrome and Ehlers\u2013Danlos syndrome"],"prefix":"10.1111","volume":"96","author":[{"given":"Hel\u00e9ne E. K.","family":"Sundelin","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Hospital Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Stephansson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Karolinska University Hospital and Institute Stockholm Sweden"},{"name":"School of Public Health University of California Berkeley CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Johansson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Karolinska University Hospital and Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm Sweden"},{"name":"Department of Pediatrics University Hospital \u00d6rebro Sweden"},{"name":"Division of Epidemiology and Public Health School of Medicine University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/751768"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36805"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31429"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.53"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000123"},{"key":"e_1_2_8_7_1","first-page":"281","article-title":"Obstetric and gynecologic dysfunction in the Ehlers\u2010Danlos syndrome","volume":"39","author":"Sorokin Y","year":"1994","journal-title":"J Reprod Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810403.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35506"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020930"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000175529.42615.42"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S64251"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9350-y"},{"key":"e_1_2_8_15_1","volume-title":"The Swedish Medical Birth Register \u2013 a summary of content and quality","author":"K\u00e4ll\u00e9n B","year":"2003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_8_17_1","volume-title":"Born too soon: the global action report on preterm birth","author":"March of Dimes, PMNCH, Save the Children, WHO","year":"2012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.12.007"},{"key":"e_1_2_8_19_1","first-page":"697","article-title":"Perinatal complications associated with preterm deliveries at 24 to 33\u00a0weeks and 6\u00a0days gestation (2011\u20132012): a hospital\u2010based retrospective study","volume":"13","author":"Khoshnood Shariati M","year":"2015","journal-title":"Iran J Reprod Med"},{"key":"e_1_2_8_20_1","volume-title":"Taglio cesareo: una scelta appropriata e consapevole. 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