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We hypothesized that adverse outcome in children with fetal growth restriction at primary school age is associated with fetoplacental circulatory abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Comprehensive ultrasonographic assessment of fetoplacental hemodynamics was performed in 72 growth\u2010restricted fetuses prenatally, and short\u2010term outcome data were collected. At the median age of 9\u00a0years, mortality and morbidity were determined using medical charts and questionnaires. The impact of abnormal fetoplacental hemodynamics on mortality and morbidity with significant developmental disorders or delay were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetal growth restriction children with adverse long\u2010term outcome were delivered earlier and with lower birthweights than were those with non\u2010compromised outcome. Seventy percent of the fetal growth restriction group showed non\u2010compromised long\u2010term outcomes and participated in mainstream education at the appropriate age level. Absent\/retrograde diastolic flow in the umbilical artery (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), negative A\u2010wave in the ductus venosus (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006), cardiomegaly (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02), hydrops (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006) and cardiovascular profile score &lt;6 (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002) were associated with increased risk of adverse outcome. After adjustment for gestational age, these parameters demonstrated hazard ratios of 5.0\u201316.5 for adverse long\u2010term outcome; increased systemic venous pulsatility and low cardiovascular profile score had the highest predictive power.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Absent or reversed end\u2010diastolic flow in the umbilical artery, reversed A\u2010wave in the ductus venosus, cardiomegaly, hydrops, and low cardiovascular profile score are associated with adverse outcomes at primary school age in fetal growth restriction children. These fetal parameters play a significant role in the prediction of long\u2010term outcomes for fetal growth restriction children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13052","type":"journal-article","created":{"date-parts":[[2016,11,5]],"date-time":"2016-11-05T04:49:30Z","timestamp":1478321370000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fetal hemodynamics and adverse outcome in primary school\u2010aged children with fetal growth restriction: a prospective longitudinal study"],"prefix":"10.1111","volume":"96","author":[{"given":"Noora","family":"Korkalainen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Oulu University Hospital Oulu Finland"},{"name":"PEDEGO Research Unit University of Oulu Oulu 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