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Randomized clinical trials, retrospective and prospective cohort studies, and case control studies were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>In all, 468 abstracts were identified and 84 added from selected article bibliographies; of these, 503 abstracts were excluded, leaving 49 articles as the basis of review.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>The literature supports corticosteroids for <jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content> up to 32\u201334\u00a0weeks without chorioamnionitis. Antenatal corticosteroids are beneficial for preterm infants of women with <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> (hemolysis, elevated liver enzymes, low platelets) syndrome\/severe preeclampsia. Postpartum corticosteroid treatment of <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> patients results in more rapid correction of liver enzymes, platelet counts, and urinary output, which can reduce maternal morbidity. Corticosteroids in twin pregnancies decrease respiratory distress syndrome but the effect is less than in singleton pregnancies. Corticosteroid effects on intrauterine growth restriction pregnancies are conflicting and steroid use should be individualized. Corticosteroid use for 23\u201326\u00a0weeks reduces neonatal mortality but not morbidity. In pregnancies of 34\u00a0weeks to 36<jats:sup>6\/7<\/jats:sup>\u00a0weeks, corticosteroids reduce respiratory distress syndrome, but follow\u2010up studies are unavailable. No long\u2010term adverse child developmental effects have been observed with one or two courses of corticosteroids, but three or more steroid courses lowers birthweight and organ weight, and there may be an increase in neurodevelopmental abnormalities. Longer follow up of corticosteroid\u2010treated fetuses is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13104","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T14:42:45Z","timestamp":1485614565000},"page":"395-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Use of antenatal corticosteroids in special circumstances: a comprehensive review"],"prefix":"10.1111","volume":"96","author":[{"given":"Everett F.","family":"Magann","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Department of Biostatistics University of Arkansas for the Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Haram","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital Department of Public and Primary Care University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songthip","family":"Ounpraseuth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Department of Biostatistics University of Arkansas for the Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital Department of Public and Primary Care University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horace J.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital Department of Public and Primary Care University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.50.4.515"},{"key":"e_1_2_9_3_1","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerationg fetal lung maturation for women at risk for preterm birth","volume":"19","author":"Roberts D","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.86.1.65"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.108331"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90222-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70272-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994121"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)33270-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994150"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90419-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00319-5"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"S45","article-title":"Effect of corticosteroids on perinatal outcomes in preterm premature rupture of membranes","volume":"18","author":"Mazumder U","year":"2009","journal-title":"Mymensingh Med J"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90607-1"},{"issue":"5","key":"e_1_2_9_15_1","first-page":"721","article-title":"Use of ampicillin and corticosteroids in premature rupture of membranes: a randomized study","volume":"73","author":"Morales WJ","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_16_1","first-page":"55","article-title":"Premature rupture of membranes: a prospective, randomized evaluation of steroids, latent phase, and expectant management","volume":"66","author":"Nelson LH","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_17_1","first-page":"865","article-title":"The use of dexamethasone in women with preterm premature rupture of membranes \u2013 a multicentre, double\u2010blind, placebo\u2010controlled, randomised trial. 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