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We performed multivariable logistic regression to estimate the association between accelerated fetal growth occurring in the first through early second trimester as measured by ultrasound and <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content> and macrosomia at birth. Restricted analyses were performed in the groups without gestational diabetes and with normal body mass index (18.5\u201324.9 kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When adjusting for confounders, the odds of having a severely <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content> or macrosomic infant were elevated in mothers with fetuses that were at least 7 days larger than expected as compared with mothers without age discrepancy at the second\u2010trimester scan (adjusted odds ratio 1.80; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.23\u20132.64 and adjusted odds ratio 2.15; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.55\u20132.98, respectively). Additionally, mothers without gestational diabetes and mothers with normal weight had an elevated risk of having a severely <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content> or macrosomic infant when the age discrepancy by second\u2010trimester ultrasound was at least 7 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a low\u2010risk population, ultrasound\u2010estimated accelerated fetal growth in early pregnancy was associated with an increased risk of having a severely <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content> or macrosomic infant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13189","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T17:46:38Z","timestamp":1499363198000},"page":"1261-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Accelerated fetal growth in early pregnancy and risk of severe large\u2010for\u2010gestational\u2010age and macrosomic infant: a cohort study in a low\u2010risk population"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-4015","authenticated-orcid":false,"given":"Marija","family":"Simic","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Solna Karolinska University Hospital and Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna\u2010Karin","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Solna Karolinska University Hospital and Institutet Stockholm Sweden"},{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-4563","authenticated-orcid":false,"given":"Olof","family":"Stephansson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Solna Karolinska University Hospital and Institutet Stockholm Sweden"},{"name":"School of Public Health University of California Berkeley CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13268"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341813"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.302"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00179.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.12.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.02.035"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.1.60"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk071"},{"key":"e_1_2_9_10_1","first-page":"CD000938","article-title":"Induction of labour for suspected fetal macrosomia","author":"Irion O","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540180036030"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.12.1625"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39129.637917.AE"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.78"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11218"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3918"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.566653"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15780"},{"key":"e_1_2_9_19_1","unstructured":"Graviditetsregistret [Swedish Pregnancy Register].\u00c5rsrapport 2014. 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