{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:47:35Z","timestamp":1790650055981,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002702","name":"Aalborg Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008267","name":"Kong Christian den Tiendes Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008267","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recently, an association between human papillomavirus infection and both spontaneous abortion and spontaneous preterm delivery was suggested. However, the reported human papillomavirus prevalence in pregnant women varies considerably and reliable conclusions are difficult. We aimed to investigate human papillomavirus infection in placental tissue of a Danish study cohort. Furthermore, we studied the cellular localization of human papillomavirus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this prospective case\u2010control study, placental tissue was analyzed for human papillomavirus infection by nested <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> in the following four study groups: full\u2010term delivery (<jats:italic>n<\/jats:italic> = 103), spontaneous preterm delivery (<jats:italic>n<\/jats:italic> = 69), elective abortion (<jats:italic>n<\/jats:italic> = 54), and spontaneous abortion (<jats:italic>n<\/jats:italic> = 44). Moreover, human papillomavirus cellular target was identified using in situ hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human papillomavirus prevalence in placental tissue was 8.7% in full\u2010term deliveries, 8.8% in spontaneous preterm deliveries, 10.9% in spontaneous abortions, and 20.4% in elective abortions. Twelve different human papillomavirus types were detected, and placental human papillomavirus infection was associated to a disease history of cervical cancer. Human papillomavirus <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was identified in trophoblast cells, cells of the placental villi mesenchyme including Hofbauer cells, and in parts of the encasing endometrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Placental human papillomavirus infections are not likely to constitute a risk factor for spontaneous preterm labor or spontaneous abortions in the Danish population, although an effect of human papillomavirus <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> in placental cells cannot be excluded.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13190","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T08:16:41Z","timestamp":1499847401000},"page":"1188-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Human papillomavirus infects placental trophoblast and Hofbauer cells, but appears not to play a causal role in miscarriage and preterm labor"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-6039","authenticated-orcid":false,"given":"Lea M.M.","family":"Amb\u00fchl","sequence":"first","affiliation":[{"name":"Center for Clinical Research North Denmark Regional Hospital Hj\u00f8rring Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K.","family":"Leonhard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Widen Zakhary","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology North Denmark Regional Hospital Hj\u00f8rring 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