{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:06:25Z","timestamp":1775693185558,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to assess the accuracy of the non\u2010invasive fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic> test at 24\u201326 weeks of gestation as part of the national antenatal screening program to target routine antenatal anti\u2010D prophylaxis (<jats:styled-content style=\"fixed-case\">RAADP<\/jats:styled-content>) at 28\u201330 weeks at women carrying an RhD\u2010positive fetus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A prospective cohort study involving all maternity care centers and delivery hospitals in Finland between February 2014 and January 2016. Fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic> genotyping using cell\u2010free fetal <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> in maternal plasma was performed with real\u2010time polymerase chain reaction in a centralized setting. The results were systematically compared with the serological newborn RhD typing. The main outcome measure was the accuracy of the fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic> assay; the secondary variable was compliance with the newly introduced <jats:styled-content style=\"fixed-case\">RAADP<\/jats:styled-content> program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic> was screened from 10 814 women. For the detection of fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic>, sensitivity was 99.99% [95% confidence interval (CI) 99.92\u201399.99] and specificity 99.81% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 99.60\u201399.92). One false\u2010negative and seven false\u2010positive results were reported by the delivery hospitals in two years. The negative predictive value of the test was 99.97% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 99.81\u201399.99). At the end of the study period, over 98% of the RhD\u2010negative women participated in the new screening program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The targeted <jats:styled-content style=\"fixed-case\">RAAPD<\/jats:styled-content> program was implemented effectively in the national maternity care program in Finland. An accurate fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic> screening test allows discontinuation of newborn testing without risking the postnatal prophylaxis program. In the future, the main area to investigate will be the clinical effect of <jats:styled-content style=\"fixed-case\">RAADP<\/jats:styled-content> on subsequent pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13191","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T04:18:41Z","timestamp":1500351521000},"page":"1228-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Targeted antenatal anti\u2010D prophylaxis program for RhD\u2010negative pregnant women \u2013 outcome of the first two years of a national program in Finland"],"prefix":"10.1111","volume":"96","author":[{"given":"Katri","family":"Haimila","sequence":"first","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kati","family":"Sulin","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malla","family":"Kuosmanen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Sareneva","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Korhonen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvi","family":"Natunen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarno","family":"Tuimala","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8908-8605","authenticated-orcid":false,"given":"Susanna","family":"Sainio","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"CD000020","article-title":"Anti\u2010D administration in pregnancy for preventing Rhesus alloimmunisation","volume":"2","author":"Crowther CA","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12590"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02174-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60534-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39518.463206.25"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03362.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825d33d9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13100"},{"key":"e_1_2_9_10_1","volume-title":"Guide book 30","author":"Klemetti R","year":"2013"},{"key":"e_1_2_9_11_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2016"},{"key":"e_1_2_9_12_1","unstructured":"StevensonMwith contributions fromNunesT HeuerC MarshallJ SanchezJ ThorntonR ReiczigelJ et al.epiR: Tools for the Analysis of Epidemiological Data. 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