{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:07:45Z","timestamp":1775142465599,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Both women with polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) and women with twin pregnancies have increased risk of adverse pregnancy outcome. The aim of this study was to investigate the impact of <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and maternal androgen levels on the outcome of dichorionic twin pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A retrospective study of 360 women with dichorionic twin pregnancies: 72 women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> from a fertility clinic (years 1997\u20132010) and 288 women without <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> from a hospital cohort (years 2005\u20132007). The obstetrical outcome was extracted from Danish National registers and supplemented by patient file data. In all, 65% of the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> group had a registered prepregnancy androgen level and these were stratified into normoandrogenic and hyperandrogenic women. The groups were compared by multiple regression analysis adjusting for mode of conception and prepregnancy body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no overall impact of <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> on the pregnancy outcome; the risks of preeclampsia, gestational diabetes and preterm delivery were comparable within the groups. However, five deliveries in the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> group compared with two in the control group occurred before gestational week 28. No difference in the obstetrical outcome between hyperandrogenic and normoandrogenic women was found. The body mass index in the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> population was lower than in the non\u2010<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, possibly reflecting a higher socioeconomic status and a healthier lifestyle, which may underestimate the impact of a <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neither <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> nor maternal androgen levels confer additional risks to the outcome of dichorionic twin pregnancies of normal weight women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13241","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T19:22:37Z","timestamp":1507231357000},"page":"1453-1459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Obstetrical complications in dichorionic twin pregnancies in women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-9406","authenticated-orcid":false,"given":"Fjola","family":"Jonsdottir","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Hvidovre University Hospital Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-7132","authenticated-orcid":false,"given":"Lisbeth","family":"Nilas","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Hvidovre University Hospital Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten R.","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Hvidovre University Hospital Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Grinsted","sequence":"additional","affiliation":[{"name":"The Fertility Clinic Trianglen Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders Statens Serum Institut Copenhagen Denmark"},{"name":"Department of Biomedical Science University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula L.","family":"Hedley","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara V.","family":"Naver","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Hvidovre University Hospital Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen 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