{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:11:54Z","timestamp":1792422714472,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The cause of recurrent pregnancy loss often remains unknown. Possibly, pathophysiological pathways are shared with other pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>All women with secondary recurrent pregnancy loss (<jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content>) visiting Leiden University Medical Center (January 2000\u20132015) were included in this retrospective cohort to assess whether women with <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> have a more complicated first pregnancy compared with control women. <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> was defined as three or more consecutive pregnancy losses before 22 weeks of gestation, with a previous birth. The control group consisted of all Dutch nullipara delivering a singleton (January 2000\u20132015). Information was obtained from the Dutch Perinatal Registry. Outcomes were preeclampsia, preterm birth, post\u2010term birth, intrauterine growth restriction, breach position, induction of labor, cesarean section, congenital abnormalities, perinatal death and severe hemorrhage in the first ongoing pregnancy. Subgroup analyses were performed for women with idiopathic <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> and for women \u226435 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 172 women with <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> and 1 196 178 control women were included. Women with <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> were older and had a higher body mass index; 29.7 years vs. 28.8 years and 25.1 kg\/m<jats:sup>2<\/jats:sup> vs. 24.1 kg\/m<jats:sup>2<\/jats:sup>, respectively. Women with <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> more often had a post\u2010term birth (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.86, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.10\u20133.17) and more perinatal deaths occurred in women with <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> compared with the control group (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.03, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.48\u201310.2). Similar results were found in both subgroup analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The first ongoing pregnancy of women with (idiopathic) <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> is more often complicated by post\u2010term birth and perinatal death. Revealing possible links between <jats:styled-content style=\"fixed-case\">SRPL<\/jats:styled-content> and these pregnancy complications might lead to a better understanding of underlying pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13248","type":"journal-article","created":{"date-parts":[[2017,10,21]],"date-time":"2017-10-21T05:32:37Z","timestamp":1508563957000},"page":"82-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pregnancy before recurrent pregnancy loss more often complicated by post\u2010term birth and perinatal death"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-0792","authenticated-orcid":false,"given":"Marise M.","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jantien","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjo","family":"Verburg","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal W.P.M.","family":"Hukkelhoven","sequence":"additional","affiliation":[{"name":"Perined Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.M.","family":"Van Lith","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1377-4625","authenticated-orcid":false,"given":"Kitty W.M.","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center Leiden the Netherlands"},{"name":"Division Women and Baby Department of Obstetrics Birth Center University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92159-F"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.1.102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu299"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.11.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00599.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2012.01121.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2010.10.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq091"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-004-0640-z"},{"key":"e_1_2_8_11_1","unstructured":"Available online at:https:\/\/www.perined.nl(accessed March 2017)."},{"key":"e_1_2_8_12_1","volume-title":"Richtlijn Herhaalde Miskraam. 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