{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:31:22Z","timestamp":1785371482855,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007634","name":"Ida Montinin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>) has a well\u2010known risk of congenital heart defects with poor prognosis. This study was conducted to determine the national total prevalence and prenatal detection rates of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> with heart defects and its association with major extra\u2010cardiac malformations and to further evaluate the impact of the heart defect severity on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A 10\u2010year national cohort was derived from four national registries, including live births, stillbirths, and terminations of pregnancy for fetal anomalies. The study cohort was sorted according to cardiac defect severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total prevalence of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> with heart defects was 0.6\/10\u00a0000 births and live birth prevalence 0.3\/10\u00a0000 live births. Of 145 cases with <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>, 37 (26%) had a concurrent heart defect. The overall prenatal detection rate of heart defects was 41%. The total prevalence (483\/10\u00a0000) and live birth prevalence (500\/10\u00a0000) of hypoplastic left heart syndrome were 124 and 250 times higher than in the general population in Finland, respectively. Additional major extra\u2010cardiac malformations were found in 68% of cases. The survival rate for <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> with major heart defects was 11 and 38% with minor heart defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The total prevalence of hypoplastic left heart syndrome was significantly higher in <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> patients than in the general population in Finland. Prenatal detection rate for heart defects in <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> patients was 41%. Major extra\u2010cardiac malformations were more common than previously reported. The prognosis of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> with major heart defects remained poor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13274","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T11:37:06Z","timestamp":1512646626000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Congenital diaphragmatic hernia with heart defect has a high risk for hypoplastic left heart syndrome and major extra\u2010cardiac malformations: 10\u2010year national cohort from Finland"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5960-6088","authenticated-orcid":false,"given":"Johanna","family":"Hautala","sequence":"first","affiliation":[{"name":"Obstetrics, and Gynecology Women's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2643-2568","authenticated-orcid":false,"given":"Emma","family":"Karstunen","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Children's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-7219","authenticated-orcid":false,"given":"Annukka","family":"Ritvanen","sequence":"additional","affiliation":[{"name":"Finnish Register of Congenital Malformations Information Services Department National Institute for Health and Welfare THL Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1460-1857","authenticated-orcid":false,"given":"Risto","family":"Rintala","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Children's Hospital Helsinki University and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka P.","family":"Mattila","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery Children's Hospital Helsinki University and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-5936","authenticated-orcid":false,"given":"Juha","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[{"name":"Obstetrics, and Gynecology Women's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3365-5965","authenticated-orcid":false,"given":"Pertti K.","family":"Suominen","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Children's Hospital Helsinki University and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-7763","authenticated-orcid":false,"given":"Tiina","family":"Ojala","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Children's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.07.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.06.048"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14648"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7497"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.02.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1067\/mpd.2002.125004","article-title":"Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia","volume":"41","author":"Cohen MS","year":"2002","journal-title":"J Pediatr"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.12.021"},{"key":"e_1_2_10_10_1","unstructured":"Eurocat\u2010network.eu:Minor Anomalies for Exclusion.http:\/\/www.eurocat-network.eu\/content\/Section%203.2-%2027_Oct2016.pdf(accessed 13 November 2017)."},{"key":"e_1_2_10_11_1","unstructured":"National institute for Health and Welfare RitvanenA.Ep\u00e4muodostumat 1993\u20132011 \u2013 Congenital anomalies 1993\u20132011. 28 February 2014.http:\/\/urn.fi\/URN:NBN:fi-fe201402284344(accessed 13 November 2017)."},{"key":"e_1_2_10_12_1","first-page":"S51","volume-title":"Birth Defects Res. Part A Clin. Mol. Teratol.","author":"Greenlees R","year":"2011"},{"key":"e_1_2_10_13_1","unstructured":"EUROCAT.Calculation of Prevalence Rates.http:\/\/www.eurocat-network.eu\/accessprevalencedata\/interpretationguide\/calculationofprevalencerates(accessed 13 November 2017)."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14790"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7747"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00635.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3367"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7586"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.08.016"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.13274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T20:51:08Z","timestamp":1695847868000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,27]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/aogs.13274"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13274","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,27]]},"assertion":[{"value":"2017-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}