{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:25:18Z","timestamp":1790749518456,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:00:00Z","timestamp":1519344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002702","name":"Aalborg Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006304","name":"Aalborg Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Current knowledge of the fetoplacental vasculature in fetal growth restriction (\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      ) due to placental dysfunction focuses on the microvasculature rather than the macrovasculature. The aim of this study was to investigate the feasibility of computed tomography angiography to analyze the fetoplacental macrovasculature in normal and\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      We included 29 placentas (22\u201342\u00a0weeks of gestation) from normal birthweight pregnancies and eight placentas (26\u201337\u00a0weeks of gestation) from\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      pregnancies (birthweight\u00a0&lt;\u00a0\u221215% and abnormal umbilical Doppler flow). We performed postpartum placental computed tomography angiography followed by semi\u2010automatic three\u2010dimensional image segmentation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A median of nine (range seven to eleven) vessel generations was identified. In normal birthweight placentas, gestational age was positively linearly correlated with macrovascular volume (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.002), vascular surface area (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.0005) and number of vessel junctions (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.012), but not with vessel diameter and inter\u2010branch length. The\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      placentas had a lower weight (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.004) and smaller convex volume (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.022) (smallest convex volume containing the macrovasculature); however, macrovascular volume was not significantly reduced. Hence, macrovascular density given as macrovascular outcomes per placental volume was increased in\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      placentas: macrovascular volume per convex volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004), vascular surface area per convex volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004) and number of vessel junctions per convex volume (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Evaluation of the fetoplacental macrovasculature is feasible with computed tomography angiography. In normal birthweight placentas, macrovascular volume and surface area increase as pregnancy advances by vessel branching rather than increased vessel diameter and elongation. The\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      placenta was smaller; however, the macrovascular volume was within normal range because of an increased macrovascular density.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.13289","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T10:24:09Z","timestamp":1515061449000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Postpartum computed tomography angiography of the fetoplacental macrovasculature in normal pregnancies and in those complicated by fetal growth restriction"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-3180","authenticated-orcid":false,"given":"Mette \u00d8.","family":"Thunbo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and 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