{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:18:43Z","timestamp":1773112723144,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The purpose of this study was to determine the feasibility of human Papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) testing alone as a prognostic tool to predict recurrent disease within a three\u2010year follow\u2010up period after treatment for cervical intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>)2<jats:sup>+<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Retrospectively, 128 women with histologically verified <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2<jats:sup>+<\/jats:sup> who had a conization performed at Southern Jutland Hospital in Denmark between 1 January 2013 and 31 December 2013 were included. Histology, cytology and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test results were obtained for a three\u2010year follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>4.7% (6\/128) of the cases developed recurrent disease during follow\u2010up. Of the cases without free margins, recurrent dysplasia was detected normal in 10.4% (5\/48), whereas in the group with free margins it was 1.3% (1\/80). The post\u2010conization <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test was negative in 67.2% (86\/128) and Pap smear normal in 93.7% (120\/128). Combining resection margins, cytology and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> had sensitivity for prediction of recurrent dysplasia of 100%. Specificity was 45.8%, positive predictive value (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>) 8.5% and negative predictive value (<jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content>) 100%. Using <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test alone as a predictor of recurrent dysplasia gave a sensitivity of 83.3%, specificity 69.7%, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> 11.9% and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> 98.8%. Combining resection margin and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test had a sensitivity of 100%, specificity 45.9%, <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> 8.3% and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test at six months control post\u2010conization gave an <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of 98.8% and can be used as a solitary test to identify women at risk for recurrent disease three years after treatment for precursor lesions. Using both resection margin and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test had a sensitivity of 100% and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> 100%. Adding cytology did not increase the predictive value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13325","type":"journal-article","created":{"date-parts":[[2018,2,11]],"date-time":"2018-02-11T11:02:35Z","timestamp":1518346955000},"page":"758-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["<scp>HPV<\/scp>\u2010testing versus <scp>HPV<\/scp>\u2010cytology co\u2010testing to predict the outcome after conization"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-2870","authenticated-orcid":false,"given":"L\u00e6rke Vals\u00f8e","family":"Bruhn","sequence":"first","affiliation":[{"name":"Department of Pathology Southern Jutland Hospital S\u00f8nderborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisse Josephine","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Pathology Southern Jutland Hospital S\u00f8nderborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalil","family":"Hariri","sequence":"additional","affiliation":[{"name":"Department of Pathology Southern Jutland Hospital S\u00f8nderborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7361"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70078-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00404.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12173"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200407000-00024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00965.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1298-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2016.27.e3"},{"key":"e_1_2_8_10_1","first-page":"245","article-title":"Human Papillomavirus combined with cytology and margin status identifies patients at risk for recurrence after conization for high\u2010grade cervical intraepithelial neoplasia","volume":"36","author":"Ruano Y","year":"2015","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1689"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.13503"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.08.135"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23824"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2015.528"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.095"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2012.23.4.217"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31828543c5"},{"key":"e_1_2_8_19_1","first-page":"CD010757","article-title":"Follow\u2010up strategies after treatment (large loop excision of the transformation zone (LLETZ)) for cervical intraepithelial neoplasia (CIN): impact of human Papillomavirus (HPV) test","volume":"1","author":"van der Heijden E","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318285423c"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.049"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182216fef"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.11.1500"},{"key":"e_1_2_8_24_1","unstructured":"Sundhedsstyrelsen.Screening for livmoderhalskr\u00e6ft. Anbefalinger 2012.2012. Available online at:http:\/\/www.sst.dk\/~\/media\/B1211EAFEDFB47C5822E883205F99B79.ashx."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.01.015"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.12.018"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.063"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01063.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0845"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12960"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12601"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437423"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30700-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.06.032"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3633"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.13325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:00:19Z","timestamp":1695474019000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/aogs.13325"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13325","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]},"assertion":[{"value":"2017-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}