{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:53:23Z","timestamp":1740124403948,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003749","name":"L\u00e4nsstyrelsen \u00d6sterg\u00f6tland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Obese women have increased leptin levels and longer duration of labor compared with normal\u2010weight women. Leptin has an inhibitory effect on myometrial contractility in vitro. Our purpose was to examine whether maternal leptin levels in active labor were associated with the duration of the active phase of labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This prospective cohort study included 914 women. Maternal blood samples were collected in active labor. The plasma\u2010leptin concentration was obtained using a direct sandwich\u2010based ELISA. Bivariate and multiple linear regression analyses were used to study the association between leptin levels and the duration of labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 1\u00a0ng\/mL increase in maternal plasma leptin was associated with a 0.015\u00a0hour increase in duration of labor (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.007). This association was not statistically significant in the adjusted analyses nor when analyzing nulliparous and multiparous women separately. In women with spontaneous labor (n\u00a0=\u00a0766) leptin levels were not associated with an increase in duration of labor in the adjusted analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no significant association between leptin levels and duration of the active phase of labor. Leptin in vivo might display a similar dose\u2010response effect on myometrial contractility as demonstrated in in vitro studies. Future studies need to explore the association between leptin levels and time in labor in obese women with high leptin levels to evaluate a possible dose\u2010response effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13380","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T17:43:50Z","timestamp":1526579030000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Maternal plasma leptin levels in relation to the duration of the active phase of labor"],"prefix":"10.1111","volume":"97","author":[{"given":"Sara","family":"Carlh\u00e4ll","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology and Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-2630","authenticated-orcid":false,"given":"Karin","family":"K\u00e4ll\u00e9n","sequence":"additional","affiliation":[{"name":"Institution of Clinical Sciences Lund Center for Reproductive Epidemiology Tornblad Institute Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Thorsell","sequence":"additional","affiliation":[{"name":"Center for Social and Affective Neuroscience Department of Clinical and Experimental Medicine Faculty of Health Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-550X","authenticated-orcid":false,"given":"Marie","family":"Blomberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2016.01.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000107291.46159.00"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20620"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665111003077"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2012.12.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.08.021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000142713.53197.91"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.04.038"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02889.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01233.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.05.041"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.11.035"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12487"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(09)70073-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.172"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40608-016-0108-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.106"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.01.020"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13100"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.07.039"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328332d24e"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149918"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41847"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.104844"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.02.001"},{"key":"e_1_2_9_28_1","first-page":"225","article-title":"Intrauterine pressure during the second stage of labor in obese women","volume":"103","author":"Buhimschi CS","year":"2004","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_29_1","unstructured":"Statistics on pregnancies deliveries and newborn infants.2015. 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