{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:23:19Z","timestamp":1769577799391,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fetal heart rate short term variation (<jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content>) decreases with severe chronic hypoxia in the antenatal period. However, only limited research has been done on <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> during labor. We have tested a novel algorithm for a valid baseline estimation and calculated <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content>. To explore the value of <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> during labor, we compared <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> with fetal scalp blood (<jats:styled-content style=\"fixed-case\">FBS<\/jats:styled-content>) lactate concentration, an early marker in the hypoxic process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Software was developed which estimates baseline frequency using a novel algorithm and thereby calculates <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> according to Dawes and Redman in up to four 30\u2010minute blocks prior to each <jats:styled-content style=\"fixed-case\">FBS<\/jats:styled-content>. Cardiotocography traces from 1070 women in labor who had had <jats:styled-content style=\"fixed-case\">FBS<\/jats:styled-content> performed on 2134 occasions were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In acidemic cases (lactate &gt;4.8\u00a0mmol\/L; Lactate Pro\u2122), median <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> 30\u00a0minutes prior to <jats:styled-content style=\"fixed-case\">FBS<\/jats:styled-content> was 7.10\u00a0milliseconds compared with 6.09\u00a0milliseconds in the preacidemic (4.2\u20104.8\u00a0mmol\/L) and 5.23\u00a0milliseconds in the normal (&lt;4.2\u00a0mmol\/L) groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). There was a positive correlation between lactate and <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> (rho\u00a0=\u00a00.16\u20100.24; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Median lactate concentration in cases with <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> &lt;3.0\u00a0milliseconds (n\u00a0=\u00a0160) was 2.3\u00a0mmol\/L. When 2 <jats:styled-content style=\"fixed-case\">FBS<\/jats:styled-content> were performed within 60\u00a0minutes the change rate of lactate correlated to <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> (rho\u00a0=\u00a00.33; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Cases with increasing lactate concentration had a median <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> of 5.29\u00a0milliseconds vs 4.41\u00a0milliseconds in those with decreasing lactate (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the early stages of intrapartum hypoxia, <jats:styled-content style=\"fixed-case\">STV<\/jats:styled-content> increases, contrary to findings regarding chronic hypoxia in the antenatal period. The increase in the adrenergic surge is a likely explanation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13390","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T07:04:31Z","timestamp":1527231871000},"page":"1274-1280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Fetal heart rate short term variation during labor in relation to scalp blood lactate concentration"],"prefix":"10.1111","volume":"97","author":[{"given":"Ke","family":"Lu","sequence":"first","affiliation":[{"name":"School of Technology and Health Royal Institute of Technology  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-0753","authenticated-orcid":false,"given":"Malin","family":"Holzmann","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Patient Area Pregnancy and Delivery Care Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahrad","family":"Abtahi","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Physiology Karolinska University Hospital Huddinge  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Lindecrantz","sequence":"additional","affiliation":[{"name":"School of Technology and Health Royal Institute of Technology  Stockholm Sweden"},{"name":"Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-8235","authenticated-orcid":false,"given":"Pelle G","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Patient Area Pregnancy and Delivery Care Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7547-2569","authenticated-orcid":false,"given":"Lennart","family":"Nordstrom","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Patient Area Pregnancy and Delivery Care Karolinska University Hospital  Stockholm 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