{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:34:55Z","timestamp":1787243695013,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective of this narrative review was to suggest a rational order of treatment choices in anovulatory women with polycystic ovary syndrome (\n                    <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                    ), for whom a multitude of treatment options exist. In obese\/overweight women with\n                    <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                    the importance of weight reduction should be stressed. Inositol, a dietary supplement with a documented effect on ovulation and without adverse effects in the doses recommended, may be suggested. Additional first\u2010line medical alternatives include insulin sensitizers, selective estrogen receptor modulators, and aromatase inhibitors. Of these, the aromatase inhibitor letrozole and the combination of clomiphene citrate and metformin have the highest rates of ovulation and live birth. Second\u2010line treatments are ovarian electrocautery and low\u2010dose follicle\u2010stimulating hormone stimulation. Controlled ovarian stimulation with in vitro fertilization, should be considered the last option as it carries a significant risk of ovarian hyperstimulation syndrome in patients with\n                    <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/aogs.13395","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T14:01:05Z","timestamp":1528725665000},"page":"1162-1167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Ovulation induction in polycystic ovary syndrome"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-4866","authenticated-orcid":false,"given":"Tom","family":"Tanbo","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mellembakken","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Bjercke","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ring","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"\u00c5byholm","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fedorcsak","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt061"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.7.2248"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1580"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.2.0394"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341679"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.03.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00990.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw025"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61182-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2016-0122"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90303-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.04.043"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.06.030"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.736557"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-16-0385"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq045"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.147492"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1902-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405789"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.08.024"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14754"},{"key":"e_1_2_9_26_1","first-page":"931","article-title":"Inositol safety: clinical evidences","volume":"15","author":"Carlomagno G","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_27_1","first-page":"CD011507","article-title":"Antenatal dietary supplementation with myo\u2010inositol in women during pregnancy for preventing gestational diabetes","volume":"12","author":"Crawford TJ","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu037"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0030"},{"key":"e_1_2_9_30_1","first-page":"CD003053","article-title":"Insulin\u2010sensitising drugs (metformin, rosiglitazone, pioglitazone, d\u2010chiro\u2010inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility","volume":"11","author":"Morley LC","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_31_1","first-page":"CD006105","article-title":"Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome","volume":"11","author":"Tso LO","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei042"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.07.044"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002418"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574886311666160627094051"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex035"},{"key":"e_1_2_9_37_1","first-page":"CD002249","article-title":"Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome","volume":"12","author":"Brown J","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh840"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1973.tb11230.x"},{"key":"e_1_2_9_40_1","first-page":"31","article-title":"The control of FSH secretion","volume":"288","author":"McNeilly AS","year":"1988","journal-title":"Acta Endocrinol Suppl (Copenh)"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.05.078"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.230"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.03.014"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313517"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108219"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309013348"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.009"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(39)90764-7"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.7.1479"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349409006253"},{"key":"e_1_2_9_51_1","first-page":"CD001122","article-title":"Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome","volume":"23","author":"Farquhar C","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des336"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000175351.18308.3a"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1272476"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0063"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi036"},{"key":"e_1_2_9_57_1","unstructured":"Centers for Disease Control and Prevention.2015Assisted Reproductive Technology National Summary Report.https:\/\/www.cdc.gov\/art\/reports\/2015\/national-summary.html. Accessed June 21 2018."},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00788.x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.09.017"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j138"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.13395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:53:18Z","timestamp":1694933598000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,24]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/aogs.13395"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13395","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,24]]},"assertion":[{"value":"2017-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}