{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:01:21Z","timestamp":1784286081522,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T00:00:00Z","timestamp":1535241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to compare oncological outcomes and morbidity in patients with early\u2010stage vulvar cancer with negative sentinel lymph node (SLN) biopsy vs negative inguinofemoral lymphadenectomy (IFL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Study with retrospectively collected data in patients with squamous cell vulvar carcinomas \u2264\u00a04\u00a0cm without suspected inguinofemoral lymph node metastases. Only patients with negative nodes after histopathology procedure were followed. Patients who underwent only SLN were compared with patients who underwent IFL\u00a0\u00b1\u00a0SLN to compare recurrences, survival rates and morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010three patients were eligible for follow up: 42 with negative SLN and 51 with negative IFL\u00a0\u00b1\u00a0SLN. The median follow\u2010up period was 60.4\u00a0months (range 6.7\u2010160.7). The rate of isolated first groin recurrence was 4.8% in patients with negative SLN and 2.0% in patients with negative IFL\u00a0\u00b1\u00a0SLN (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.587) and the rates of first isolated local recurrence were 28.6% and 31.4%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.823). Only 1 patient (2.4%) in the group of negative SLN had distant recurrence. The disease\u2010specific survival rate at 5\u00a0years was 83.3% in the negative SLN group and 92.2% in the negative IFL\u00a0\u00b1\u00a0SLN group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.214). We observed a higher rate of wound breakdown and infection after IFL than SLN biopsy (17.6% vs 10.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.020) and lymphedema (33.3% vs 0%; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report in the same population of patients with early\u2010stage vulvar cancer that SLN biopsy does not have significantly higher rates of groin recurrences or lower survival rates compared with IFL. Moreover, the SLN procedure has less morbidity, which should encourage gynecologists to abandon IFL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13431","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T12:21:52Z","timestamp":1533126112000},"page":"1427-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term oncological outcomes of patients with negative sentinel lymph node in vulvar cancer. 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