{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:21:11Z","timestamp":1772518871007,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Previous reports have shown that suboptimal antenatal corticosteroids administration occurs in most cases. However, as multifetal gestations were either excluded or constituted a small proportion of the participants in these studies, little is known about the patterns of use of antenatal corticosteroids in twin pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We reviewed the records of women who received antenatal corticosteroids and delivered between 24<jats:sup>0\/7<\/jats:sup> and 34<jats:sup>6\/7<\/jats:sup> weeks of gestation during 2015\u20102017 at 2 university hospitals. Optimal antenatal corticosteroids timing was defined as delivery \u226524\u00a0hours \u22647\u00a0days from the previous antenatal corticosteroids course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 424 pregnancies, 307 (72.4%) were singleton and 117 were (27.6%) twin. For twin compared with singleton pregnancies, gestational age at initial antenatal corticosteroids administration was lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), the proportion of deliveries within the optimal window of the initial antenatal corticosteroids course was lower (19.7% vs 33.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), and the proportion of women eligible for a rescue antenatal corticosteroids course was higher (58.1% vs 32.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). However, despite similar rates of rescue antenatal corticosteroids administration (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.64), the overall rate of delivery within any optimal window (either initial or rescue course) was lower in twin than singleton pregnancies (26.5% vs 42.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), and the antenatal corticosteroids\u2010to\u2010delivery interval was longer (median 6.9 vs 4.2\u00a0days, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0009). In multivariate analysis, optimal antenatal corticosteroids administration was negatively associated with twin pregnancy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) and preterm labor (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05), and positively associated with the presence of gestational hypertensive disorders (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Twin pregnancy is an independent risk factor for suboptimal antenatal corticosteroids administration. Directed efforts should be made to improve the utilization of antenatal corticosteroids in this vulnerable group of women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13439","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T08:28:36Z","timestamp":1533976116000},"page":"1508-1514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Patterns of use and optimal timing of antenatal corticosteroids in twin compared with singleton pregnancies"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2472-5204","authenticated-orcid":false,"given":"Amihai","family":"Rottenstreich","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah\u2010Hebrew University Medical Center Jerusalem 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Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simcha","family":"Yagel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uriel","family":"Elchalal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3769"},{"key":"e_1_2_9_3_1","unstructured":"2012 World Health Organization Geneva Switzerland March of Dimes PMNCH Save the Children WHO CP Howson MV Kinney JE Lawn Born too soon: the global action report on preterm 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