{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:21:59Z","timestamp":1784118119519,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003744","name":"Stiftelsen Handlanden Hjalmar Svenssons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Large observational studies have shown that obstetric and perinatal outcomes are negatively affected in obese women. In contrast, a recent Dutch randomized trial of infertile women and lifestyle weight intervention found no difference between the weight intervention group and the control group in obstetric or neonatal outcomes. We have recently published a large Nordic randomized trial where obese women scheduled for in vitro fertilization (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) treatment went through an intensive weight intervention treatment before <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>. No significant effect on live birth rate was found, despite large weight loss in the intervention group. The present study was conducted primarily to find out the effect of weight intervention in obese women scheduled for <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> on mean birthweight and mean deviation from expected birthweight, and secondarily the effect on other perinatal and maternal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A secondary analysis of a prospective, randomized controlled trial performed between 2010 and 2016 in the Nordic countries was performed. In all, 317 women were randomized either to weight reduction and <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a0160) or <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> only (<jats:italic>n<\/jats:italic>\u00a0=\u00a0157) and the primary end\u2010point was live birth. From this study, all births were analyzed for perinatal and maternal outcomes. Nine infertility clinics participated, including women &lt;\u00a038\u00a0years of age planning for <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>, and having a body mass index \u2265\u00a030 and &lt;\u00a035\u00a0kg\/m<jats:sup>2<\/jats:sup>. Data concerning perinatal and maternal outcomes were gathered from maternal health\u2010care and delivery records for mother and child. All analyses were performed on singletons only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 87 live births, 45 singletons in the intervention group and 41 singletons and one twin birth in the control group. The maternal characteristics for the women having a live birth were comparable in the two groups. The primary outcomes, mean birthweight, in the weight intervention and <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> group and the <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> only group were; 3486\u00a0g (standard deviation [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>] 523) vs 3584\u00a0g (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 509) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.46), mean difference \u221298.6\u00a0g (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] \u2212320.3 to 123.2); deviation from expected birthweight 0.25% (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 10.4) vs 0.87% (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 12.9), mean difference 1.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22126.1 to 3.9). The estimates of the secondary perinatal and maternal outcomes in the 2 groups were: preterm birth &lt;\u00a037\u00a0weeks 2 (4.4%) vs 1 (2.4%) (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 1.95; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.17\u201022.36), small\u2010for\u2010gestational\u2010age 0 (0%) vs 1 (2.4%), mean gestational age (days) 278 vs 280 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.95), preeclampsia 5 (11.1%) vs 4 (9.8%) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.19; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.30\u20104.76), cesarean section 13 (28.9%) vs 10 (24.4%) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.14; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.45\u20102.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The outcomes in both groups were generally good. There are no indications that weight intervention in this setting, in infertile women with obesity <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> class 1 undergoing <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>, has a negative impact on mean birthweight and deviation from expected birthweight. However, the data are not sufficiently robust to draw firm conclusions concerning other outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13532","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T23:01:49Z","timestamp":1546297309000},"page":"708-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["No effect of weight intervention on perinatal outcomes in obese women scheduled for in vitro fertilization treatment"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-2334","authenticated-orcid":false,"given":"Snorri","family":"Einarsson","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences Sahlgrenska Academy Gothenburg University Gothenburg Sweden"},{"name":"Livio Reykjavik Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6049-7731","authenticated-orcid":false,"given":"Christina","family":"Bergh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences Sahlgrenska Academy Gothenburg University Gothenburg Sweden"},{"name":"Reproductive Medicine Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Kluge","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences Sahlgrenska Academy Gothenburg University Gothenburg Sweden"},{"name":"Reproductive Medicine Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Thurin\u2010Kjellberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences Sahlgrenska Academy Gothenburg University Gothenburg Sweden"},{"name":"Reproductive Medicine Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq325"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der241"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.03.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.028"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000107291.46159.00"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000219768.08249.b6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1290"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh485"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.1100"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq306"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505297"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex235"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182245d49"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_10_16_1","unstructured":"European Surveillance of Congenital Anomalies E Twins CAoCAa Registration. 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