{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:12:06Z","timestamp":1762409526821,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003744","name":"Stiftelsen Handlanden Hjalmar Svenssons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009240","name":"Sveriges Kommuner och Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Increasing evidence suggests that cervical intraepithelial neoplasia, with or without subsequent treatment, is associated with preterm delivery. We aimed to explore the association between abnormal cervical cytology of different severity and the subsequent obstetric outcomes such as preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The historical register\u2010based cohort study comprised 19\u00a0822 women in the Western Region of Sweden who had at least one abnormal cervical cytology from 1978 to 2012 before the age of 45 and a subsequent singleton delivery. The reference group comprised 39\u00a0644 women with normal cervical cytology and a subsequent singleton delivery, matched by age and parity. Data were retrieved from the Swedish National Cervical Screening Registry, linked to the Swedish Medical Birth Register and Statistic Sweden. The study outcomes were spontaneous preterm delivery before 37 and 34\u00a0weeks, low birthweight (\u22642500\u00a0g), small\u2010for\u2010gestational\u2010age, preterm premature rupture of membranes and neonatal mortality. Multivariable log binominal regression analyses were applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preterm delivery before 37\u00a0weeks was more common among women with abnormal cervical cytology compared with reference group: 6% vs 4.5%; adjusted relative risk 1.30 (95% confidence interval 1.21\u20101.39). High vs low\u2010grade abnormal cervical cytology implied a higher risk: 7% vs 5.8% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Early preterm delivery before 34\u00a0weeks, preterm premature rupture of membranes and low birthweight, but not small\u2010for\u2010gestational\u2010age and neonatal mortality, were significantly more common in women with abnormal cervical cytology compared with the reference group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal cervical cytology may imply an increased risk of preterm delivery. Further studies are needed to investigate whether that risk is related to treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aogs.13543","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T23:36:06Z","timestamp":1548286566000},"page":"777-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal cervical cytology is associated with preterm delivery: A population based study"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4394-6299","authenticated-orcid":false,"given":"Tagrid","family":"Jar\u2010Allah","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-1733","authenticated-orcid":false,"given":"Cecilia","family":"K\u00e4rrberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-2035","authenticated-orcid":false,"given":"Johanna","family":"Wiik","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics \u00d8stfold Hospital Trust  Kalnes Norway"},{"name":"Department of Obstetrics and Gynecology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3608-7430","authenticated-orcid":false,"given":"Verena","family":"Sengpiel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-7955","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Strander","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Swedish National Cervical Screening Registry Regional Cancer Center  West Sweden Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Oncology Institute of Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-5388","authenticated-orcid":false,"given":"Annika","family":"Strandell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn099"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.12.021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1284"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.07.038"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31828caa31"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706475"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60560-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6223"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13398"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03252.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b5cba3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181d068a3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP93JMIUEKRPIW"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem404"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12132"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01107.x"},{"key":"e_1_2_9_18_1","unstructured":"Nationellt Kvalitetsregister f\u00f6r Cervixcancerprevention_Analys.2018.http:\/\/nkcx.se\/index.htm. Accessed May 1 2018."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"e_1_2_9_20_1","unstructured":"Longitudinal integration database for health insurance and labour market studies (LISA). \u00d6rebro 2018.https:\/\/www.scb.se\/en\/services\/guidance-for-researchers-and-universities\/vilka-mikrodata-finns\/longitudinella-register\/longitudinal-integration-database-for-health-insurance-and-labour-market-studies-lisa\/. Accessed May 1 2018."},{"volume-title":"Cervical Cancer Prevention Studies on Possible Improvements","year":"2007","author":"Strander B","key":"e_1_2_9_21_1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00765.x"},{"key":"e_1_2_9_24_1","first-page":"CD012847","article-title":"Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease","volume":"11","author":"Kyrgiou M","year":"2017","journal-title":"Cochrane Database System Rev"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001777"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5174"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03052.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02438.x"},{"issue":"1","key":"e_1_2_9_29_1","first-page":"81","article-title":"Pregnancy outcomes after cold knife conization related to excised cone dimensions. A retrospective cohort study","volume":"59","author":"Sozen H","year":"2014","journal-title":"J Reprod Med"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(03)00016-8"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253239.87040.23"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faogs.13543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.13543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.13543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:29:26Z","timestamp":1694356166000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/aogs.13543"],"URL":"https:\/\/doi.org\/10.1111\/aogs.13543","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"type":"print","value":"0001-6349"},{"type":"electronic","value":"1600-0412"}],"subject":[],"published":{"date-parts":[[2019,2,13]]},"assertion":[{"value":"2018-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}