{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:18Z","timestamp":1787013858260,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,24]],"date-time":"2019-02-24T00:00:00Z","timestamp":1550966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The advent of RhD immunoglobulin prophylaxis to prevent maternal RhD alloimmunization has reduced the incidence of this condition and its associated poor outcomes. Consequently, non\u2010D Rh antibodies now account for a greater proportion of alloimmunized pregnancies. These antibodies have been the subject of comparatively little research. This study investigated the incidence and clinical outcome of pregnancies affected by non\u2010D Rh alloimmunization at an Australian tertiary maternity service.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective study of all pregnancies with non\u2010D Rh antibodies (namely anti\u2010C, \u2010E, \u2010c, \u2010e, \u2010C\n                      <jats:sup>w<\/jats:sup>\n                      as well as the compound antibodies anti\u2010CD, \u2010cE and \u2010ce) managed at the Royal Women's Hospital, Victoria, Australia, from 2009 to 2013 inclusive. Information collected included maternal demographics, details of the antibodies, course of the pregnancy and neonatal outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 115 non\u2010D Rh alloimmunized pregnancies were identified in 102 mothers. Forty\u2010nine pregnancies reached the critical titer (&gt;\u00a016) from non\u2010D Rh alone and 11 fetuses received intrauterine red blood cell transfusion. Labor was induced or cesarean section performed in 38 cases. Forty\u2010three neonates were admitted to the special care nursery and 59 received phototherapy. Nine received treatment for anemia and 10 neonates received intravenous immunoglobulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010D Rh alloimmunization is a relatively uncommon complication of pregnancy, occurring in only .33% of pregnancies in the study period. It can lead to significant fetal\/neonatal morbidity (and may lead to mortality). The most severe outcomes (including perinatal deaths) were mostly associated with the compound antibodies anti\u2010CD and anti\u2010cE, or a non\u2010D Rh antibody in conjunction with anti\u2010D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.13555","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:29:55Z","timestamp":1549412995000},"page":"877-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["How clinically important are non\u2010D Rh antibodies?"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-8152","authenticated-orcid":false,"given":"Susan","family":"Healsmith","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology The University of Melbourne The Royal Women's Hospital Parkville Victoria Australia"},{"name":"Pregnancy Research Center Department of Maternal Fetal Medicine The Royal Women's Hospital Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynecology Sunshine Hospital Western Health St Albans Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Savoia","sequence":"additional","affiliation":[{"name":"Department of Hematology The Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Department of Clinical Hematology The Royal Women's Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-3263","authenticated-orcid":false,"given":"Stefan C.","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The University of Melbourne The Royal Women's Hospital Parkville Victoria Australia"},{"name":"Pregnancy Research Center Department of Maternal Fetal Medicine The Royal Women's Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12099"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12091"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.181172"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31826d7dc1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01984.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2002.00399.x"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"25","article-title":"Obstetric management in Rh alloimmunizated pregnancy","volume":"3","author":"Cacciatore A","year":"2009","journal-title":"J Prenatal Med"},{"key":"e_1_2_10_9_1","unstructured":"National Health and Medical Research Council.Ethical Considerations in Quality Assurance and Evaluation Activities. 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